Molecular epidemiology and antifungal susceptibility of dermatophytes and Candida isolates in superficial fungal infections at a grade A tertiary hospital in Northern China.

IF 2.7 3区医学 Q3 INFECTIOUS DISEASES Medical mycology Pub Date : 2024-09-06 DOI:10.1093/mmy/myae087

Ruijun Zhang, Ziping Song, Xiaorui Su, Ting Li, Juan Xu, Xiao He, Yuanwen Yang, Bingmei Chang, Yuying Kang

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Abstract

This study analyzed the prevalence and antifungal susceptibility of superficial fungal infections in 295 cases from 2019 to 2020 at a dermatology clinic. Dermatophytes were the predominant pathogens (69.5%), including Trichophytonrubrum, T. interdigitale, Microsporum canis, et al., followed by Candida spp. (29.5%), including Candidaalbicans, Ca. parapsilosis, and Ca. glabrata. The most common infections were onychomycosis (36.3%), tinea cruris (30.5%), and tinea corporis (18.6%). The distribution of SFI types showed variations based on gender, age, and season. Common antifungal agents, including terbinafine, voriconazole, ciclopiroxamine, amphotericin B, itraconazole, and ketoconazole have exhibited low minimum inhibitory concentrations against dermatophytes, especially terbinafine, which has been potent against superficial fungal infections caused by dermatophytes in the local area. Candida spp. strains were generally susceptible or classified as wild-type to 5-flucytosine and amphotericin B, with 92.0% being wild-type for itraconazole. However, resistance to fluconazole and voriconazole was observed in a small percentage of Ca. albicans and Ca. parapsilosis strains. The emergence of drug-resistant Candida underscores the importance of prudent antifungal use and continuous surveillance.

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华北某甲级三甲医院浅部真菌感染中皮真菌和念珠菌分离物的分子流行病学和抗真菌敏感性

本研究分析了2019年至2020年一家皮肤科诊所295例浅表真菌感染的患病率和抗真菌敏感性。皮肤真菌是最主要的病原体（69.5%），包括红色毛癣菌（T. rubrum）、趾间毛癣菌、犬小孢子菌等，其次是白色念珠菌属（29.5%），包括白色念珠菌（C. albicans）、副丝状念珠菌（C. parapsilosis）和格拉布氏念珠菌（C. glabrata）。最常见的感染是甲癣（36.3%）、股癣（30.5%）和体癣（18.6%）。SFI类型的分布因性别、年龄和季节而异。特比萘芬、伏立康唑、环吡酮胺、两性霉素 B、伊曲康唑和酮康唑等常用抗真菌药物对皮癣菌的最低抑菌浓度（MIC）较低，尤其是特比萘芬，对本地皮癣菌引起的 SFI 有较强的抑制作用。念珠菌属菌株一般对 5-氟胞嘧啶和两性霉素 B 敏感或属于野生型，其中 92.0%对伊曲康唑属于野生型。不过，在一小部分白念珠菌和副丝状念珠菌中发现了对氟康唑和伏立康唑的耐药性。耐药性念珠菌的出现凸显了谨慎使用抗真菌药物和持续监控的重要性。

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.