Alterations in aperiodic and periodic EEG activity in young children with Down syndrome

IF 5.1 2区 医学 Q1 NEUROSCIENCES Neurobiology of Disease Pub Date : 2024-08-20 DOI:10.1016/j.nbd.2024.106643
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Abstract

Down syndrome (DS) is the most common cause of intellectual disability, yet little is known about the neurobiological pathways leading to cognitive impairments. Electroencephalographic (EEG) measures are commonly used to study neurodevelopmental disorders, but few studies have focused on young children with DS. Here we assess resting state EEG data collected from toddlers/preschoolers with DS (n = 29, age 13–48 months old) and compare their aperiodic and periodic EEG features with both age-matched (n = 29) and developmental-matched (n = 58) comparison groups. DS participants exhibited significantly reduced aperiodic slope, increased periodic theta power, and decreased alpha peak amplitude. A majority of DS participants displayed a prominent peak in the theta range, whereas a theta peak was not present in age-matched participants. Overall, similar findings were also observed when comparing DS and developmental-matched groups, suggesting that EEG differences are not explained by delayed cognitive ability.

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唐氏综合征幼儿非周期性和周期性脑电图活动的变化。
唐氏综合症(DS)是导致智力障碍的最常见原因,但人们对导致认知障碍的神经生物学途径却知之甚少。脑电图(EEG)测量通常用于研究神经发育障碍,但很少有研究关注患有唐氏综合症的幼儿。在这里,我们评估了从患有 DS 的幼儿/学龄前儿童(n = 29,年龄 13-48 个月)收集的静息状态脑电图数据,并将他们的非周期性和周期性脑电图特征与年龄匹配组(n = 29)和发育匹配组(n = 58)进行了比较。DS 参与者的非周期性斜率明显降低,周期性θ功率增加,α峰值振幅降低。大多数罹患聋哑的参与者在θ范围内表现出明显的峰值,而年龄匹配的参与者则没有θ峰值。总体而言,在比较聋儿组和发育匹配组时也观察到了类似的结果,这表明脑电图的差异并不能用认知能力的延迟来解释。
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来源期刊
Neurobiology of Disease
Neurobiology of Disease 医学-神经科学
CiteScore
11.20
自引率
3.30%
发文量
270
审稿时长
76 days
期刊介绍: Neurobiology of Disease is a major international journal at the interface between basic and clinical neuroscience. The journal provides a forum for the publication of top quality research papers on: molecular and cellular definitions of disease mechanisms, the neural systems and underpinning behavioral disorders, the genetics of inherited neurological and psychiatric diseases, nervous system aging, and findings relevant to the development of new therapies.
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