Effectiveness and Safety of the Allurion Swallowable Intragastric Balloon for Short-term Weight Loss: A Systematic Review and Meta-analysis.

IF 2.9 3区医学 Q1 SURGERY Obesity Surgery Pub Date : 2024-10-01 Epub Date: 2024-08-23 DOI:10.1007/s11695-024-07453-5

Adriana Fernandes Silva, Alexandre Moraes Bestetti, Angelo So Taa Kum, Beanie Conceição Medeiros Nunes, Matheus de Oliveira Veras, Wanderley Marques Bernardo, Eduardo Guimarães Hourneaux de Moura

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Abstract

Background: Obesity poses a severe health problem worldwide, with an estimated impact on 17.5% of the adult population by 2035. Among the endoscopic applications for treating this comorbidity, intragastric balloons are the most widely used. The new liquid-filled swallowable balloon meets the requirements of major guidelines and allows significant weight loss with few adverse events. This systematic review and meta-analysis aims to demonstrate the efficacy and safety profile of this new device for weight loss.

Methods: We conducted a search from 2016 to 2024 to assess the efficacy of the swallowable intragastric balloon for weight loss, including improvements in metabolic profiles and anthropometric measurements. Additionally, we evaluated potential adverse events related to the device to demonstrate its safety.

Results: Eleven observational studies totalling 2107 patients were included, showing a reduction of 4.75 in BMI (95% CI: -5.02; -4.47), a mean total weight loss of 12.47% (95% CI: -13.77; -11.17), a mean excess weight loss of 48.04% (95% CI: -50.61; -45.48), and a rate of serious adverse events of 0.90%. An improvement in the metabolic profile was observed for three parameters: HDL, triglycerides, and glycaemia.

Conclusion: The swallowable liquid-filled intragastric balloon is safe and effective for managing weight loss within a four-month follow-up period.

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用于短期减肥的 Allurion 可吞咽胃内球囊的有效性和安全性：系统回顾和 Meta 分析。

背景：肥胖症是全球严重的健康问题，预计到 2035 年，17.5% 的成年人会受到肥胖症的影响。在治疗肥胖症的内窥镜应用中，胃内气球的应用最为广泛。新型液体填充可吞咽气球符合主要指南的要求，可显著减轻体重，且不良反应少。本系统综述和荟萃分析旨在证明这种新型减肥设备的疗效和安全性：我们对 2016 年至 2024 年的数据进行了检索，以评估可吞咽胃内球囊的减肥疗效，包括代谢状况和人体测量指标的改善情况。此外，我们还评估了与该装置相关的潜在不良事件，以证明其安全性：结果：共纳入了 11 项观察性研究，共计 2107 名患者，结果显示 BMI 下降了 4.75（95% CI：-5.02；-4.47），平均总重量下降了 12.47%（95% CI：-13.77；-11.17），平均超重下降了 48.04%（95% CI：-50.61；-45.48），严重不良事件发生率为 0.90%。在三个参数方面观察到了新陈代谢状况的改善：结论：结论：在四个月的随访期内，可吞咽液体填充胃内球囊对于控制体重减轻是安全有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Surgery 医学-外科

CiteScore

5.80

自引率

24.10%

发文量

567

审稿时长

3-6 weeks

期刊介绍： Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions. Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.