Factors Associated with Recurrence of Ameloblastoma: A Scoping Review.

IF 3.2 Q2 PATHOLOGY Head & Neck Pathology Pub Date : 2024-08-23 DOI:10.1007/s12105-024-01686-7

Pornnutcha Inthong, Witsarut Upalananda, Jay Saepoo

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Abstract

Purpose: This scoping review aimed to identify factors associated with the recurrence of ameloblastoma.

Methods: Systematic searches were conducted in PubMed, Scopus, and EMBASE, based on the board research question: "What factors are related to the recurrence of ameloblastoma?". English-language observational studies addressing the risk and preventive factors associated with recurrent ameloblastoma were included and data were extracted.

Results: Eighty-three retrospective observational studies met the inclusion criteria. The identified prognostic factors for recurrence included: (1) Tumor size/diameter/volume, (2) cortical bone perforation/ soft tissue invasion, (3) multilocular radiolucency, (4) impacted tooth-involving lesions, (5) root resorption, (6) WHO classification - conventional (solid/multicystic) ameloblastoma, (7) histological subtype - mural invasion of unicystic ameloblastoma, (8) conservative treatment modalities - simple enucleation, curettage, and marsupialization, and (9) non-extraction/preservation of involved teeth. No strong evidence linked immunohistochemical expression to recurrence. Interestingly, BRAF p.V600E remained controversial in terms of recurrence, despite being a frequent finding in ameloblastoma.

Conclusion: Certain clinical characteristics, radiographic findings, histological subtypes, and treatment choices of ameloblastoma can help identify patients at high risk of recurrence. Further prospective studies to evaluate the prognostic factor model and research on immunohistochemistry are required.

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釉母细胞瘤复发的相关因素：范围界定综述。

目的：本范围综述旨在确定与羊膜母细胞瘤复发相关的因素：根据板块研究问题，在 PubMed、Scopus 和 EMBASE 中进行了系统检索："与母细胞瘤复发有关的因素有哪些？研究纳入了与复发性母细胞瘤相关的风险和预防因素的英文观察性研究，并提取了相关数据：结果：83 项回顾性观察研究符合纳入标准。已确定的复发预后因素包括(1)肿瘤大小/直径/体积；(2)皮质骨穿孔/软组织侵犯；(3)多形性放射性透明；(4)影响牙齿的病变；(5)牙根吸收；(6)WHO分类--常规（实性/多囊性）骨髓母细胞瘤、(7) 组织学亚型--壁侵袭单囊性母细胞瘤，(8) 保守治疗方法--单纯去核、刮治和髓核切除术，以及 (9) 不拔除/保留受累牙齿。没有强有力的证据表明免疫组化表达与复发有关。有趣的是，尽管BRAF p.V600E在骨髓母细胞瘤中经常出现，但在复发方面仍存在争议：结论：某些临床特征、放射学检查结果、组织学亚型以及母细胞瘤的治疗选择有助于识别高复发风险患者。需要进一步开展前瞻性研究，以评估预后因素模型和免疫组化研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.