Impact of radiomics features, pulmonary emphysema score and muscle mass on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies.

IF 5.8 2区 医学 Q1 Medicine Respiratory Research Pub Date : 2024-08-22 DOI:10.1186/s12931-024-02936-6
Jakob Leonhardi, Ulrike Dahms, Benedikt Schnarkowski, Manuel Florian Struck, Anne-Kathrin Höhn, Sebastian Krämer, Sebastian Ebel, Gordian Prasse, Armin Frille, Timm Denecke, Hans-Jonas Meyer
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Abstract

Iatrogenic pneumothorax is a relevant complication of computed tomography (CT)-guided percutaneous lung biopsy. The aim of the present study was to analyze the prognostic significance of texture analysis, emphysema score and muscle mass derived from CT-imaging to predict postinterventional pneumothorax after CT-guided lung biopsy. Consecutive patients undergoing CT-guided percutaneous lung biopsy between 2012 and 2021 were analyzed. Multivariate logistic regression analysis included clinical risk factors and CT-imaging features to detect associations with pneumothorax development. Overall, 479 patients (178 females, mean age 65 ± 11.7 years) underwent CT-guided percutaneous lung biopsy of which 180 patients (37.5%) developed pneumothorax including 55 patients (11.5%) requiring chest tube placement. Risk factors associated with pneumothorax were chronic-obstructive pulmonary disease (COPD) (p = 0.03), age (p = 0.02), total lung capacity (p < 0.01) and residual volume (p = 0.01) as well as interventional parameters needle length inside the lung (p < 0.001), target lesion attached to pleura (p = 0.04), and intervention duration (p < 0.001). The combined model demonstrated a prediction accuracy of the occurrence of pneumothorax with an AUC of 0.78 [95%CI: 0.70-0.86] with a resulting sensitivity 0.80 and a specificity of 0.66. In conclusion, radiomics features of the target lesion and the lung lobe CT-emphysema score are predictive for the occurrence of pneumothorax and need for chest insertion after CT-guided lung biopsy.

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放射组学特征、肺气肿评分和肌肉质量对 CT 引导肺活检中气胸和胸管插入率的影响。
先天性气胸是计算机断层扫描(CT)引导下经皮肺活检的一种相关并发症。本研究旨在分析 CT 图像中的纹理分析、肺气肿评分和肌肉质量对预测 CT 引导下肺活检术后介入性气胸的预后意义。研究分析了2012年至2021年间接受CT引导经皮肺活检术的连续患者。多变量逻辑回归分析包括临床风险因素和CT成像特征,以检测气胸发生的相关性。共有 479 名患者(178 名女性,平均年龄 65 ± 11.7 岁)接受了 CT 引导下经皮肺活检,其中 180 名患者(37.5%)出现气胸,包括 55 名患者(11.5%)需要放置胸管。与气胸相关的风险因素有:慢性阻塞性肺病(COPD)(p = 0.03)、年龄(p = 0.02)、总肺活量(p = 0.05)、胸腔积液(p = 0.05
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来源期刊
Respiratory Research
Respiratory Research RESPIRATORY SYSTEM-
CiteScore
9.70
自引率
1.70%
发文量
314
审稿时长
4-8 weeks
期刊介绍: Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.
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