An opportunity missed: Strengthening health system data on multisystem inflammatory syndrome in children from low- and middle-income countries in Asia

IF 2.2 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Public Health in Practice Pub Date : 2024-08-18 DOI:10.1016/j.puhip.2024.100535
D.S. Ong , P.V. Licciardi , K. Mulholland , L.A.H. Do
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Abstract

Background

Multisystem inflammatory syndrome in children (MIS-C) is a severe complication associated with SARS-CoV-2 infection. The clinical epidemiology of MIS-C is not completely understood in low- and middle-income countries (LMICs) due to limited reporting, including in Asia where there was a substantial burden of COVID-19. We aimed to discuss the challenges of diagnosing MIS-C and factors which may cause children from Asian LMICs to have an increased risk of MIS-C.

Methods

Not applicable.

Results

The burden of MIS-C in Asian LMICs may be disproportionately high due to underlying risk factors, resource-limited health systems, and the increased infectivity and transmissibility of recent SARS-CoV-2 variants. Complex clinical features of MIS-C contributed to missed or delayed diagnosis and treatment, while underlying risk factors including ethnicity, chronic health conditions, and socioeconomic factors may have predisposed children in Asian LMICs to MIS-C.

Conclusions

There was a lack of data on the clinical epidemiology of MIS-C in Asian LMICs during the COVID-19 pandemic, despite reports of higher paediatric mortality rates compared to high-income countries. This highlights the need for LMICs to have strong surveillance systems to collect high-quality and timely data on newly emerging complications associated with a pandemic, such as MIS-C. This will lead to rapid understanding of these emerging complications, and inform clinical management, disease prevention and health system planning.

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错失良机:加强亚洲中低收入国家儿童多系统炎症综合征的卫生系统数据
背景儿童多系统炎症综合征(MIS-C)是与 SARS-CoV-2 感染相关的一种严重并发症。由于报告有限,中低收入国家(LMICs)对 MIS-C 的临床流行病学尚不完全了解,包括 COVID-19 在亚洲造成巨大负担的国家。我们旨在讨论诊断 MIS-C 所面临的挑战,以及可能导致亚洲 LMIC 儿童感染 MIS-C 风险增加的因素。MIS-C的临床特征复杂,导致漏诊或延误诊断和治疗,而包括种族、慢性健康状况和社会经济因素在内的潜在风险因素可能使亚洲低收入与中等收入国家的儿童更容易感染MIS-C。结论在COVID-19大流行期间,尽管有报道称亚洲低收入与中等收入国家的儿科死亡率高于高收入国家,但缺乏有关亚洲低收入与中等收入国家MIS-C临床流行病学的数据。这突出表明,低收入与中等收入国家需要建立强大的监测系统,及时收集与大流行相关的新出现并发症(如 MIS-C)的高质量数据。这将有助于迅速了解这些新出现的并发症,并为临床管理、疾病预防和卫生系统规划提供信息。
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来源期刊
Public Health in Practice
Public Health in Practice Medicine-Health Policy
CiteScore
2.80
自引率
0.00%
发文量
117
审稿时长
71 days
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