Xi Cheng , Chunping Cui , Shishi Shen , Zhibin Li , Yipeng Zhao , Caixia Li , Allan G. Kermode , Xiaonan Zhong , Wei Qiu
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引用次数: 0
Abstract
Intestinal microbes play a crucial role in gut health and the immune-mediated central nervous system through the “gut-brain” axis. However, probiotic safety and efficacy in Neuromyelitis optica spectrum disorder (NMOSD) are not well-explored. A pilot clinic trial for NMOSD with probiotic intervention revealed alterations in the microbiota (increased Anaerostipes, Bacteroides; decreased Granulicatella, Streptococcus, Rothia). Metabolite analysis showed elevated 2-methylbutyric and isobutyric acids, reduced lithocholic acid (LCA), and glycodeoxycholic acid (GDCA). Immune markers Interleukin (IL-7), vascular endothelial growth factor (VEGF-A), and B lymphocyte chemoattractant (BLC) decreased, while plasma cells and transitional B cells increased post-probiotics, suggesting potential immunomodulatory effects on NMOSD.
肠道微生物通过 "肠-脑 "轴在肠道健康和免疫介导的中枢神经系统中发挥着至关重要的作用。然而，益生菌对神经性脊髓炎视网膜频谱紊乱症（NMOSD）的安全性和疗效尚未得到充分探讨。一项针对神经性脊髓炎视网膜频谱紊乱症的益生菌干预试点临床试验显示，该病的微生物群发生了改变（厌氧菌、乳酸杆菌增加；肉毒杆菌、链球菌、轮虫减少）。代谢物分析表明，2-甲基丁酸和异丁酸升高，石胆酸（LCA）和糖脱氧胆酸（GDCA）降低。免疫标记物白细胞介素（IL-7）、血管内皮生长因子（VEGF-A）和 B 淋巴细胞趋化因子（BLC）减少，而浆细胞和过渡性 B 细胞在使用益生菌后增加，这表明益生菌对 NMOSD 有潜在的免疫调节作用。
期刊介绍：
The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.
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