Peritoneal and renal DKK3 clearance in peritoneal dialysis.

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY BMC Nephrology Pub Date : 2024-08-23 DOI:10.1186/s12882-024-03715-7

Hagen Ehleiter, Julia Miranda, Dominik Boes, Uta Scheidt, Sibylle von Vietinghoff, Sebastian Schwab

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Abstract

Background: Urinary Dickkopf 3 (DKK3) excretion is a recently established biomarker of renal functional development. Its excretion into the peritoneal cavity has not been reported. We here studied DKK3 in peritoneal dialysis.

Methods: DKK3 was assessed in serum, urine and dialysate in a prevalent adult peritoneal dialysis cohort and its concentration analyzed in relation to creatinine and clinical characteristics.

Results: Highest DKK3 concentrations were found in serum, followed by urine. Dialysate concentrations were significantly lower. Dialysate DKK3 correlated with both other compartments. Serum, dialysate and urine values were stable during three months of follow-up. Continuous ambulatory dialysis (CAPD) but not cycler-assisted peritoneal dialysis (CCPD) volume-dependently increased peritoneal DKK3 in relation to creatinine. RAAS blockade significantly decreased urinary, but not serum or peritoneal DKK3.

Conclusion: Our data provide a detailed characterization of DKK3 in peritoneal dialysis. They support the notion that the RAAS system is essential for renal DKK3 handling.

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腹膜透析中腹膜和肾脏对 DKK3 的清除率。

背景：尿液中 Dickkopf 3 (DKK3) 的排泄量是最近确立的肾功能发育生物标志物。它在腹腔中的排泄量尚未见报道。我们在此研究了腹膜透析中的 DKK3：方法：在一个流行的成人腹膜透析队列中评估血清、尿液和透析液中的 DKK3，并分析其浓度与肌酐和临床特征的关系：结果：血清中的 DKK3 浓度最高，其次是尿液。透析液中的浓度明显较低。透析液中的 DKK3 与其他两个分区相关。在三个月的随访期间，血清、透析液和尿液中的浓度值保持稳定。持续非卧床透析（CAPD）而非循环器辅助腹膜透析（CCPD）的透析量与腹膜DKK3与肌酐的关系无关。RAAS 阻断剂能明显降低尿液中的 DKK3，但不能降低血清或腹膜中的 DKK3：我们的数据提供了腹膜透析中 DKK3 的详细特征。结论：我们的数据提供了腹膜透析中 DKK3 的详细特征，支持 RAAS 系统对肾脏 DKK3 处理至关重要的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.30

自引率

0.00%

发文量

375

审稿时长

3-8 weeks

期刊介绍： BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.