The effect of dulaglutide on glycated hemoglobin is associated with PNPLA3 Ι148Μ gene polymorphism in patients with type 2 diabetes mellitus.

IF 3.7 3区医学 Q2 Medicine Endocrine Pub Date : 2024-08-23 DOI:10.1007/s12020-024-04007-8

Stylianos Gavriilidis, Rozalia Andrianopoulou, Charikleia Ntenti, Anna Sarakapina, Christina Trakatelli, Stergios A Polyzos, Antonis Goulas

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Abstract

Purpose: The evaluation of the effect of dulaglutide on glycated hemoglobin (HbA1c) and non-invasive indices of hepatic steatosis among different genotypes of the PNPLA3 I148M (rs738409) and CETP Taq1B (rs708272) polymorphisms in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD).

Methods: Relevant data from patients with inadequately controlled T2DM, also displaying NAFLD, administered 1.5 mg dulaglutide weekly for 6 months were retrospectively retrieved. The non-invasive indices, fatty liver index (FLI) and hepatic steatosis index (HSI), were calculated. Genotyping for rs738409 and rs708272 were performed with polymerase chain reaction.

Results: Data from 80 patients (39 females), aged 64.4 ± 9.5 years and displaying a baseline BMI of 34.5 ± 5.8 kg/m², were retrieved at baseline and after 6 months (endpoint) of dulaglutide treatment. Glycated hemoglobin (HbA1c; -0.72 ± 1.10%; p < 0.001), FLI (-5.8 ± 9.8; p < 0.001) and HSI (-1.18 ± 3.51; p = 0.004) significantly decreased after treatment. Lipid profile and liver function tests also improved after treatment. Overall, homozygotes for the reference rs738409 allele (CC) displayed a 2.4-fold decrease (p = 0.002) and heterozygotes (CG) an 1.6-fold decrease (p = 0.013) compared to GG homozygotes after treatment, but the effect was largely limited to female patients. No similar effect was observed in FLI, HSI and other relevant parameters. No association was observed between rs708272 and any of the parameters studied.

Conclusions: rs738409, but not rs708272, was associated with the effect of dulaglutide on HbA1c, but not on presumed hepatic steatosis or other relevant parameters. Sex-specific effects were also noticed.

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杜拉鲁肽对糖化血红蛋白的影响与 2 型糖尿病患者 PNPLA3 Ι148Μ 基因多态性有关。

目的：评估度拉鲁肽对2型糖尿病（T2DM）和非酒精性脂肪肝（NAFLD）患者PNPLA3 I148M（rs738409）和CETP Taq1B（rs708272）多态性不同基因型的糖化血红蛋白（HbA1c）和肝脂肪变性非侵入性指标的影响：回顾性检索了未得到充分控制的 T2DM 患者的相关数据，这些患者也患有非酒精性脂肪肝，每周服用 1.5 毫克度拉鲁肽，连续服用 6 个月。计算了非侵入性指数、脂肪肝指数（FLI）和肝脏脂肪变性指数（HSI）。通过聚合酶链反应对 rs738409 和 rs708272 进行基因分型：对 80 名患者（39 名女性）的基线和度拉鲁肽治疗 6 个月后（终点）的数据进行了检索，这些患者的年龄为 64.4 ± 9.5 岁，基线体重指数为 34.5 ± 5.8 kg/m2。糖化血红蛋白（HbA1c；-0.72 ± 1.10%；P 结论：rs738409（而非 rs708272）与度拉鲁肽对 HbA1c 的影响有关，但与推测的肝脂肪变性或其他相关参数无关。此外，还发现了性别特异性效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.