Prevalence of antibiotic-resistant Cutibacterium acnes (formerly Propionibacterium acnes) isolates, a systematic review and meta-analysis

IF 3.7 3区 医学 Q2 INFECTIOUS DISEASES Journal of global antimicrobial resistance Pub Date : 2024-08-22 DOI:10.1016/j.jgar.2024.07.005
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Abstract

Objective

This study aimed to assess the overall antibiotic susceptibility of Cutibacterium acnes (C. acnes), a bacterium implicated in acne vulgaris, with a particular focus on clindamycin and fluoroquinolones, which are commonly used in inflammatory acne treatment.

Methods

A systematic search of Scopus, PubMed, Web of Science and EMBASE databases was conducted to identify relevant studies. Pooled prevalence estimates were calculated using a random-effects model, and additional analyses included quality assessment, evaluation of publication bias, meta-regression and subgroup analyses based on antimicrobial susceptibility methods and year of publication.

Results

The analysis incorporated a total of 39 studies. The random-effects model revealed that the proportion of clindamycin-resistant isolates was 0.031 (95% CI: 0.014–0.071). Additionally, macrolides, including erythromycin (0.366; 95% CI: 0.302–0.434) and azithromycin (0.149; 95% CI: 0.061–0.322), exhibited distinct prevalence rates. Tetracyclines, including doxycycline (0.079; 95% CI: 0.014–0.071), tetracycline (0.062; 95% CI: 0.036–0.107) and minocycline (0.025; 95% CI: 0.012–0.051), displayed varying prevalence estimates. Fluoroquinolones, including ciprofloxacin (0.050; 95% CI: 0.017–0.140) and levofloxacin (0.061; 95% CI: 0.015–0.217), demonstrated unique prevalence rates. Additionally, the prevalence of the combination antibiotic trimethoprim/sulfamethoxazole (SXT) was estimated to be 0.087 (95% CI: 0.033–0.208).

Conclusion

The study findings highlight a concerning increase in antimicrobial-resistant C. acnes with the use of antibiotics in acne treatment. The strategic utilization of appropriate antimicrobials has emerged as a crucial measure to mitigate the emergence of antimicrobial-resistant skin bacteria in acne management.

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抗生素耐药痤疮杆菌(原痤疮丙酸杆菌)分离物的流行率,系统回顾和荟萃分析。
研究目的本研究旨在评估痤疮丙酸杆菌(Cutibacterium acnes,C. acnes)对抗生素的总体敏感性,特别是对克林霉素和氟喹诺酮类药物的敏感性,这两种药物是治疗炎症性痤疮的常用药物:对 Scopus、PubMed、Web of Science 和 EMBASE 数据库进行了系统检索,以确定相关研究。使用随机效应模型计算了汇总的流行率估计值,其他分析包括质量评估、发表偏倚评估、元回归以及基于抗菌药敏感性方法和发表年份的亚组分析:分析共纳入了 39 项研究。随机效应模型显示,克林霉素耐药分离株的比例为 0.031(95% CI:0.014-0.071)。此外,包括红霉素(0.366;95% CI,0.302-0.434)和阿奇霉素(0.149;95% CI,0.061-0.322)在内的大环内酯类药物显示出不同的流行率。包括多西环素(0.079;95% CI,0.014-0.071)、四环素(0.062;95% CI,0.036-0.107)和米诺环素(0.025;95% CI,0.012-0.051)在内的四环素类药物显示出不同的流行率估计值。氟喹诺酮类药物,包括环丙沙星(0.050;95% CI,0.017-0.140)和左氧氟沙星(0.061;95% CI,0.015-0.217),显示出独特的流行率。此外,复方抗生素三甲双胍/磺胺甲噁唑(SXT)的流行率估计为 0.087(95% CI:0.033-0.208):研究结果表明,随着抗生素在痤疮治疗中的使用,抗菌性痤疮丙酸杆菌的增加令人担忧。在痤疮治疗过程中,战略性地使用适当的抗菌药物已成为减少皮肤细菌对抗菌药物产生耐药性的关键措施。
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来源期刊
Journal of global antimicrobial resistance
Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY
CiteScore
8.70
自引率
2.20%
发文量
285
审稿时长
34 weeks
期刊介绍: The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.
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