Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults.

IF 2.8 3区 医学 Q2 PSYCHOLOGY, CLINICAL Journal of Behavioral Medicine Pub Date : 2024-12-01 Epub Date: 2024-08-23 DOI:10.1007/s10865-024-00515-0
Zhou Jin, Xuejian Liu, Haonan Guo, Sixuan Chen, Xianghe Zhu, Sipei Pan, Yili Wu
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Abstract

Telomere length, a biomarker of human aging, is related to adverse health outcomes. Growing evidence indicates that oxidative stress and inflammation contributes to telomere shortening, whereas social support may protect from telomere shortening. Despite sex differences in telomere length and social support, little is known about whether there are sex differences in the relationship between oxidative stress/inflammation and telomere length, and sex-specific moderating roles of social support in older adults. Using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002, this study assessed whether the associations between oxidative stress/inflammation and telomere length vary with sex and explored social support as a moderator in these associations among 2289 older adults. Oxidative stress was measured based on serum Gamma-glutamyl transferase (GGT), and inflammation was measured based on C-reactive protein (CRP). After adjusting for the covariates, GGT was significantly associated with telomere length in females only (β =  - 0.037, 95% CI =  - 0.070, - 0.005), while CRP was associated with telomere length in males only (β =  - 0.019, 95% CI =  - 0.035, - 0.002). Moreover, high social support mitigated the negative association between GGT and telomere length, which was more evident in females. Furthermore, social support moderated the association between CRP and telomere length in males aged 70 and above. Our findings indicated that biological mechanisms related to telomere length may vary with sex, while social support plays a sex-specific moderating role.

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社会支持对老年人氧化应激、炎症和端粒长度之间关系的调节作用具有性别特异性。
端粒长度是人类衰老的生物标志,与不良健康后果有关。越来越多的证据表明,氧化应激和炎症会导致端粒缩短,而社会支持可以防止端粒缩短。尽管端粒长度和社会支持存在性别差异,但人们对氧化应激/炎症和端粒长度之间的关系是否存在性别差异以及社会支持在老年人中的性别调节作用却知之甚少。本研究利用美国国家健康与营养调查(NHANES)1999-2002 年的数据,评估了氧化应激/炎症与端粒长度之间的关系是否随性别而变化,并探讨了社会支持在 2289 名老年人中对这些关系的调节作用。氧化应激根据血清γ-谷氨酰转移酶(GGT)进行测量,炎症根据C反应蛋白(CRP)进行测量。调整协变量后,GGT 仅与女性的端粒长度显著相关(β = - 0.037,95% CI = - 0.070,- 0.005),而 CRP 仅与男性的端粒长度相关(β = - 0.019,95% CI = - 0.035,- 0.002)。此外,高社会支持可减轻 GGT 与端粒长度之间的负相关,这种负相关在女性中更为明显。此外,在 70 岁及以上的男性中,社会支持缓和了 CRP 与端粒长度之间的关系。我们的研究结果表明,与端粒长度相关的生物机制可能因性别而异,而社会支持则起到了特定性别的调节作用。
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来源期刊
Journal of Behavioral Medicine
Journal of Behavioral Medicine PSYCHOLOGY, CLINICAL-
CiteScore
5.70
自引率
3.20%
发文量
112
期刊介绍: The Journal of Behavioral Medicine is a broadly conceived interdisciplinary publication devoted to furthering understanding of physical health and illness through the knowledge, methods, and techniques of behavioral science. A significant function of the journal is the application of this knowledge to prevention, treatment, and rehabilitation and to the promotion of health at the individual, community, and population levels.The content of the journal spans all areas of basic and applied behavioral medicine research, conducted in and informed by all related disciplines including but not limited to: psychology, medicine, the public health sciences, sociology, anthropology, health economics, nursing, and biostatistics. Topics welcomed include but are not limited to: prevention of disease and health promotion; the effects of psychological stress on physical and psychological functioning; sociocultural influences on health and illness; adherence to medical regimens; the study of health related behaviors including tobacco use, substance use, sexual behavior, physical activity, and obesity; health services research; and behavioral factors in the prevention and treatment of somatic disorders.  Reports of interdisciplinary approaches to research are particularly welcomed.
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