Biological aging mediates the association between periodontitis and cardiovascular disease: results from a national population study and Mendelian randomization analysis.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-08-24 DOI:10.1186/s13148-024-01732-9

Zhaoqi Zhang, Xingru Zhao, Shang Gao, An Li, Ke Deng, Kai Yang, Wei Liu, Mi Du

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Abstract

Background: The relationship between periodontitis and cardiovascular disease (CVD) has been extensively studied, but the role of biological aging in this relationship remains poorly understood. This study is dedicated to investigating the effect of periodontitis on the incidence of CVD and to elucidating the potential mediating role of biological aging. Furthermore, this study will seek to elucidate the causal association between periodontitis, CVD, and biological aging.

Methods: We included 3269 participants from the National Health and Nutrition Examination Survey (2009-2014) with diagnostic information on periodontitis and composite CVD events. Biological aging was evaluated by utilizing both the Klemera-Doubal method's calculated biological age (KDMAge) and phenotypic age (PhenoAge). Logistic regression, restricted cubic spline (RCS) analysis, and subgroup analysis were used for data analysis. Mediation analysis was employed to explore the mediating role of biological aging. Subsequently, Mendelian randomization (MR) analyses were performed using genome-wide association study databases to explore potential causal relationships between periodontitis, CVD, and biological aging.

Results: Periodontitis was associated with a higher risk of CVD. Participants with periodontitis were found to have increased levels of biological aging, and elevated levels of biological aging were associated with increased CVD risk. Mediation analyses showed a partial mediating effect of biological aging (PhenoAge: 44.6%; KDMAge: 22.9%) between periodontitis and CVD risk. MR analysis showed that periodontitis played a causal role in increasing the risk of small vessel stroke, while myocardial infarction was found to increase the risk of periodontitis. In addition, reverse MR analysis showed that phenotypic aging can increase the risk of periodontitis, and there is a two-way causal relationship between CVD and biological aging.

Conclusions: Periodontitis is associated with an increased CVD risk, partially mediated by biological aging, with a complex causal interrelationship. Targeted interventions for periodontal health may slow the biological aging processes and reduce CVD risk.

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生物老化介导牙周炎与心血管疾病之间的关系：一项全国人口研究和孟德尔随机分析的结果。

背景：牙周炎与心血管疾病（CVD）之间的关系已被广泛研究，但对生物老化在这一关系中的作用仍知之甚少。本研究致力于调查牙周炎对心血管疾病发病率的影响，并阐明生物老化的潜在中介作用。此外，本研究还将试图阐明牙周炎、心血管疾病和生物老化之间的因果关系：我们纳入了全国健康与营养调查（2009-2014 年）中 3269 名具有牙周炎诊断信息和综合心血管疾病事件的参与者。利用克莱默拉-杜巴方法计算的生物年龄（KDMAge）和表型年龄（PhenoAge）对生物衰老进行评估。数据分析采用了逻辑回归、限制性立方样条曲线（RCS）分析和亚组分析。采用中介分析来探讨生物衰老的中介作用。随后，利用全基因组关联研究数据库进行了孟德尔随机化（MR）分析，以探讨牙周炎、心血管疾病和生物衰老之间的潜在因果关系：结果：牙周炎与较高的心血管疾病风险相关。结果表明：牙周炎与心血管疾病风险的升高有关，牙周炎患者的生物老化水平升高，而生物老化水平的升高与心血管疾病风险的升高有关。中介分析显示，在牙周炎和心血管疾病风险之间，生物老化具有部分中介效应（PhenoAge：44.6%；KDMAge：22.9%）。磁共振分析显示，牙周炎在增加小血管中风风险方面起着因果作用，而心肌梗死则会增加牙周炎的风险。此外，反向磁共振分析表明，表型老化会增加牙周炎的风险，心血管疾病与生物老化之间存在双向因果关系：结论：牙周炎与心血管疾病风险的增加有关，部分由生物老化介导，两者之间存在复杂的因果关系。对牙周健康进行有针对性的干预可减缓生物衰老过程，降低心血管疾病风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.