Philipp Sahrmann, Jens Tartsch, Patrick R Schmidlin
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引用次数: 0
Abstract
Objective: Dental implants show impressive survival and like rates, but peri-implantitis is a frequent inflammatory disease which affects the implant-surrounding tissues. While biofilms on the implant surface is considered its etiologic reason, several risk factors determine the pace of progression of peri-implant bone loss. Some risk factors are generally accepted while others are still unconfirmed and a matter of ongoing discussion. Among the latter, tissue macrophage sensitization on TiO2 has gained scientific interest in recent years. The aim of the present case-control study was to test for potential associations between clinically manifest peri-implantitis and MS related parameters.
Materials and methods: In patients with implants affected by peri-implantitis in the test group and healthy implants in the control group clinical parameters (peri-implant pocket depths (PPD) and bleeding on probing (BOP) were measured. Samples of aMMP-8 were taken from the entrance of the peri-implant sulcus and bacterial samples were collected from the sulcus. Blood samples were obtained from the basilic vein to assess MA-related laboratory parameters. Potential correlations between clinical and laboratory parameters were tested by multiple regression (p < 0.05).
Results: No statistically significant correlations were found between clinical or bacteriological findings and laboratory parameters were found.
Conclusions: Based on the findings of this study elevated MA-related laboratory parameters do not appear to be linked to peri-implantitis.
Clinical relevance: Sensitization on TiO2 is not associated with clinical symptoms of peri-implantitis.
目的：种植牙的存活率和相似度都很高，但种植体周围炎是一种影响种植体周围组织的常见炎症性疾病。虽然种植体表面的生物膜被认为是其致病原因，但种植体周围骨质流失的进展速度取决于几个风险因素。一些风险因素已被普遍接受，而另一些则尚未得到证实，仍在讨论之中。其中，组织巨噬细胞对二氧化钛的敏化作用近年来受到了科学界的关注。本病例对照研究的目的是检验临床表现的种植体周围炎与 MS 相关参数之间的潜在联系：材料和方法：在受种植体周围炎影响的种植体患者中，试验组和健康种植体对照组分别测量临床参数（种植体周围袋深度（PPD）和探诊出血量（BOP））。从种植体周围沟的入口处采集 aMMP-8 样本，并从沟中采集细菌样本。从基底静脉采集血液样本以评估与 MA 相关的实验室参数。通过多元回归检验了临床和实验室参数之间的潜在相关性（P 结果：临床和实验室参数之间的相关性无统计学意义：临床或细菌学检查结果与实验室参数之间未发现有统计学意义的相关性：根据本研究的结果，MA相关实验室参数的升高似乎与种植体周围炎无关：临床意义：对二氧化钛的过敏与种植体周围炎的临床症状无关。
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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