Lysosomal membrane contact sites: Integrative hubs for cellular communication and homeostasis.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI:10.1016/bs.ctm.2024.07.001
Sumit Bandyopadhyay, Daniel Adebayo, Eseiwi Obaseki, Hanaa Hariri
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引用次数: 0

Abstract

Lysosomes are more than just cellular recycling bins; they play a crucial role in regulating key cellular functions. Proper lysosomal function is essential for growth pathway regulation, cell proliferation, and metabolic homeostasis. Impaired lysosomal function is associated with lipid storage disorders and neurodegenerative diseases. Lysosomes form extensive and dynamic close contacts with the membranes of other organelles, including the endoplasmic reticulum, mitochondria, peroxisomes, and lipid droplets. These membrane contacts sites (MCSs) are vital for many lysosomal functions. In this chapter, we will explore lysosomal MCSs focusing on the machinery that mediates these contacts, how they are regulated, and their functional implications on physiology and pathology.

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溶酶体膜接触点:细胞通讯和平衡的整合枢纽。
溶酶体不仅仅是细胞的回收箱,它们在调节关键的细胞功能方面发挥着至关重要的作用。溶酶体的正常功能对生长途径调节、细胞增殖和代谢平衡至关重要。溶酶体功能受损与脂质储存障碍和神经退行性疾病有关。溶酶体与其他细胞器(包括内质网、线粒体、过氧物酶体和脂滴)的膜形成广泛而动态的密切接触。这些膜接触点(MCS)对溶酶体的许多功能至关重要。在本章中,我们将探讨溶酶体膜接触点,重点是介导这些接触点的机制、如何调节这些接触点以及它们对生理和病理的功能影响。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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