Banking of post-SMILE stromal lenticules for additive keratoplasty: A new challenge for eye banks?

IF 1.4 4区医学 Q3 OPHTHALMOLOGY International Ophthalmology Pub Date : 2024-08-25 DOI:10.1007/s10792-024-03283-7

Raluca Bievel-Radulescu, Stefano Ferrari, Moreno Piaia, Domitilla Mandatori, Assunta Pandolfi, Mario Nubile, Leonardo Mastropasqua, Horia Tudor Stanca, Diego Ponzin

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Abstract

Purpose: ReLEx (Refractive Lenticule Extraction) Small Incision Lenticule Extraction (SMILE), the second generation of ReLEx Femtosecond Lenticule Extraction (FLEx), is a minimally invasive, flapless procedure designed to treat refractive errors such as myopia, hyperopia, presbyopia, and astigmatism. This review aims to provide a comprehensive overview of the methods for preserving SMILE-derived lenticules and discusses their potential future applications.

Methods: A narrative literature review was conducted using PubMed, Scopus, and Web of Science databases, focusing on articles published up to January 2024 and available in English. The authors also evaluated the reference lists of the collected papers to identify any additional relevant research.

Results: No standardized protocols currently exist for the storage or clinical application of SMILE-derived lenticules. However, these lenticules present a promising resource for therapeutic uses, particularly in addressing the shortage of donor corneal tissues. Their potential applications include inlay and overlay additive keratoplasty, as well as other ocular surface applications. Further research is needed to establish reliable protocols for their preservation and clinical use.

Conclusion: SMILE-derived lenticules offer significant potential as an alternative to donor corneal tissues. Standardizing their storage and application methods could enhance their use in clinical settings.

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将SMILE术后基质皮孔存入银行，用于添加角膜移植术：眼库面临的新挑战？

目的：ReLEx（屈光性皮瓣提取术）小切口皮瓣提取术（SMILE）是ReLEx飞秒皮瓣提取术（FLEX）的第二代产品，是一种微创、无瓣手术，旨在治疗近视、远视、老花和散光等屈光不正。本综述旨在全面概述保存 SMILE 衍生皮瓣的方法，并讨论其未来的潜在应用：方法：使用 PubMed、Scopus 和 Web of Science 数据库进行了叙述性文献综述，重点关注截至 2024 年 1 月发表的英文文章。作者还评估了所收集论文的参考文献目录，以确定其他相关研究：结果：目前还没有关于SMILE衍生皮孔的储存或临床应用的标准化方案。但是，这些角膜透镜是一种很有前景的治疗资源，尤其是在解决供体角膜组织短缺的问题上。它们的潜在应用包括镶嵌和覆盖添加角膜成形术，以及其他眼表应用。需要进一步开展研究，为其保存和临床使用制定可靠的方案：结论：SMILE衍生皮孔作为供体角膜组织的替代品具有巨大潜力。将其储存和应用方法标准化可提高其在临床中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.