Mitochondrial heterogeneity and crosstalk in aging: Time for a paradigm shift?

IF 7.8 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Aging Cell Pub Date : 2024-08-26 DOI:10.1111/acel.14296
Antentor O. Hinton Jr., Zer Vue, Estevão Scudese, Kit Neikirk, Annet Kirabo, Monty Montano
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Abstract

The hallmarks of aging have been influential in guiding the biology of aging research, with more recent and growing recognition of the interdependence of these hallmarks on age-related health outcomes. However, a current challenge is personalizing aging trajectories to promote healthy aging, given the diversity of genotypes and lived experience. We suggest that incorporating heterogeneity—including intrinsic (e.g., genetic and structural) and extrinsic (e.g., environmental and exposome) factors and their interdependence of hallmarks—may move the dial. This editorial perspective will focus on one hallmark, namely mitochondrial dysfunction, to exemplify how consideration of heterogeneity and interdependence or crosstalk may reveal new perspectives and opportunities for personalizing aging research. To this end, we highlight heterogeneity within mitochondria as a model.

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衰老过程中的线粒体异质性和串扰:范式转变的时机已到?
老龄化特征对指导老龄化生物学研究具有重要影响,最近,越来越多的人认识到这些特征与年龄相关的健康结果之间的相互依存关系。然而,鉴于基因型和生活经历的多样性,目前的一个挑战是个性化老龄化轨迹,以促进健康老龄化。我们认为,纳入异质性--包括内在因素(如遗传和结构)和外在因素(如环境和暴露体)以及它们与特征的相互依存关系--可能会起到推动作用。这篇社论的视角将聚焦于一个标志,即线粒体功能障碍,以举例说明对异质性和相互依存性或串扰的考虑如何为个性化老龄化研究揭示新的视角和机遇。为此,我们将线粒体内部的异质性作为一个范例加以强调。
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来源期刊
Aging Cell
Aging Cell 生物-老年医学
CiteScore
14.40
自引率
2.60%
发文量
212
审稿时长
8 weeks
期刊介绍: Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.
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