I V Gordeychuk, O S Gancharova, S A Gulyaev, T V Gulyaeva, A S Zhitkevich, D V Avdoshina, A V Moroz, A S Lunin, S E Sotskova, E A Korduban, A I Tukhvatulin, E O Bayurova, A A Ishmukhametov
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引用次数: 0
Abstract
Common marmoset (Callithrix jacchus, CM) is a New World primate species that is of interest for preclinical trials of immunobiological products. In this study, we describe the approaches to long-term laboratory breeding and maintenance of CMs. We also establish the reference values of the main complete blood count and serum chemistry parameters evaluated during preclinical trials of immunobiological products and describe the histological characteristics of CM lymphoid organs during the development of post-vaccination immune response. We show that CMs bred in laboratory conditions excluding background infectious pathology are a relevant model that allows for a high degree of reliability in characterizing the safety and immunogenicity profile of antiviral vaccines during preclinical trials.
普通狨猴（Callithrix jacchus，CM）是一种新世界灵长类动物，对免疫生物学产品的临床前试验具有重要意义。在本研究中，我们介绍了在实验室长期繁殖和维持狨猴的方法。我们还确定了免疫生物制品临床前试验期间评估的主要全血细胞计数和血清化学参数的参考值，并描述了接种疫苗后免疫反应发展过程中 CM 淋巴器官的组织学特征。我们的研究表明，在实验室条件下培育的、不存在感染性病理背景的 CM 是一种相关模型，可在临床前试验期间高度可靠地描述抗病毒疫苗的安全性和免疫原性特征。
期刊介绍：
Acta Naturae is an international journal on life sciences based in Moscow, Russia.
Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology.
Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.
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