Investigation of Ionization Chamber Characteristics for Ultrahigh-dose-rate Scanned Carbon-ion Beams.

IF 1.8 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL In vivo Pub Date : 2024-09-01 DOI:10.21873/invivo.13686
Noriaki Hamatani, Masashi Yagi, Shinichi Shimizu, Naoki Ishino, Masaki Shimizu, Yoshiaki Kuwana, Toshiro Tsubouchi, Masaaki Takashina, Takuto Miyoshi, Takuya Nomura, Takashi Toyoda, Masumi Umezawa, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, Tatsuaki Kanai
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Abstract

Background/aim: There are only a few studies on dosimetry with ultrahigh-dose-rate (uHDR) scanned carbon-ion beams. This study investigated the characteristics of four types of ionization chambers for the uHDR beam.

Materials and methods: We employed a newly developed large-plane parallel chamber to monitor a 208.3-MeV/u uHDR scanned carbon-ion beam with a 110-Gy/s average dose rate. The ionization chambers used were the Advanced Markus chamber (AMC), PinPoint 3D chamber (PPC), Farmer chamber (FC), and large-plane parallel chamber (StingRay). The AMC and StingRay surfaces and the PPC and FC geometric centers were aligned to the radiation isocenter using treatment room lasers. Using the voltage range stated in the instruction manuals, we obtained the saturation curves of the chambers. From these curves, we obtained the ion recombination correction factors using the two-voltage and three-voltage linear methods. The dose linearity was evaluated using five measurement points, and the chamber repeatability was verified by conducting repeated measurements for different dose values.

Results: Although all chambers, except for AMC, reached saturation when specified voltages were applied, they exhibited excellent linearity for different dose values. The ion recombination correction factors of the AMC obtained using the aforementioned linear methods were nearly 1. Additionally, all chambers exhibited excellent repeatability. Although the standard deviation of the PPC for the lowest dose was ~1.5%, those of all the other chambers were <1.0%.

Conclusion: All ionization chambers can be used for measuring the relative dose, and absolute dose can be conveniently measured using the AMC with an uHDR carbon-ion scanned beam.

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超高剂量率扫描碳离子束电离室特性研究
背景/目的:关于超高剂量率(uHDR)扫描碳离子束剂量测定的研究为数不多。本研究调查了用于超高剂量率碳离子束的四种电离室的特性:我们采用了新开发的大平面平行室来监测平均剂量率为 110-Gy/s 的 208.3-MeV/u uHDR 扫描碳离子束。使用的电离室包括先进马库斯电离室(AMC)、PinPoint 3D 电离室(PPC)、Farmer 电离室(FC)和大平面平行电离室(StingRay)。AMC 和 StingRay 表面以及 PPC 和 FC 的几何中心均使用治疗室激光对准辐射等中心。使用说明书中规定的电压范围,我们获得了腔室的饱和曲线。根据这些曲线,我们使用两电压和三电压线性法获得了离子重组校正因子。使用五个测量点对剂量线性进行了评估,并通过对不同剂量值进行重复测量来验证箱体的可重复性:结果:尽管除 AMC 外,所有腔室在施加指定电压时都达到了饱和状态,但它们在不同剂量值下都表现出良好的线性。使用上述线性方法获得的 AMC 离子重组校正因子接近 1。此外,所有样品室都具有出色的重复性。虽然最低剂量的 PPC 标准偏差约为 1.5%,但所有其他电离室的标准偏差均为结论:所有电离室都可用于测量相对剂量,使用超高分辨光束碳离子扫描的 AMC 可以方便地测量绝对剂量。
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来源期刊
In vivo
In vivo 医学-医学:研究与实验
CiteScore
4.20
自引率
4.30%
发文量
330
审稿时长
3-8 weeks
期刊介绍: IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.
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