Altered individual-level morphological similarity network in children with growth hormone deficiency.

IF 4.1 2区医学 Q1 CLINICAL NEUROLOGY Journal of Neurodevelopmental Disorders Pub Date : 2024-08-26 DOI:10.1186/s11689-024-09566-5

Yanglei Cheng, Liping Lin, Weifeng Hou, Huaqiong Qiu, Chengfen Deng, Zi Yan, Long Qian, Wei Cui, Yanbing Li, Zhiyun Yang, Qiuli Chen, Shu Su

{"title":"Altered individual-level morphological similarity network in children with growth hormone deficiency.","authors":"Yanglei Cheng, Liping Lin, Weifeng Hou, Huaqiong Qiu, Chengfen Deng, Zi Yan, Long Qian, Wei Cui, Yanbing Li, Zhiyun Yang, Qiuli Chen, Shu Su","doi":"10.1186/s11689-024-09566-5","DOIUrl":null,"url":null,"abstract":"Background: Accumulating evidences indicate regional grey matter (GM) morphology alterations in pediatric growth hormone deficiency (GHD); however, large-scale morphological brain networks (MBNs) undergo these patients remains unclear.Objective: To investigate the topological organization of individual-level MBNs in pediatric GHD.Methods: Sixty-one GHD and 42 typically developing controls (TDs) were enrolled. Inter-regional morphological similarity of GM was taken to construct individual-level MBNs. Between-group differences of topological parameters and network-based statistics analysis were compared. Finally, association relationship between network properties and clinical variables was analyzed.Results: Compared to TDs, GHD indicated a disturbance in the normal small-world organization, reflected by increased Lp, γ, λ, σ and decreased Cp, Eglob (all PFDR < 0.017). Regarding nodal properties, GHD exhibited increased nodal profiles at cerebellum 4-5, central executive network-related left inferior frontal gyrus, limbic regions-related right posterior cingulate gyrus, left hippocampus, and bilateral pallidum, thalamus (all PFDR < 0.05). Meanwhile, GHD exhibited decreased nodal profiles at sensorimotor network -related bilateral paracentral lobule, default-mode network-related left superior frontal gyrus, visual network -related right lingual gyrus, auditory network-related right superior temporal gyrus and bilateral amygdala, right cerebellum 3, bilateral cerebellum 10, vermis 1-2, 3, 4-5, 6 (all PFDR < 0.05). Furthermore, serum markers and behavior scores in GHD group were correlated with altered nodal profiles (P ≤ 0.046, uncorrected).Conclusion: GHD undergo an extensive reorganization in large-scale individual-level MBNs, probably due to abnormal cortico-striatal-thalamo-cerebellum loops, cortico-limbic-cerebellum, dorsal visual-sensorimotor-striatal, and auditory-cerebellum circuitry. This study highlights the crucial role of abnormal morphological connectivity underlying GHD, which might result in their relatively slower development in motor, cognitive, and linguistic functional within behavior problem performance.","PeriodicalId":16530,"journal":{"name":"Journal of Neurodevelopmental Disorders","volume":"16 1","pages":"48"},"PeriodicalIF":4.1000,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346214/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurodevelopmental Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s11689-024-09566-5","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Accumulating evidences indicate regional grey matter (GM) morphology alterations in pediatric growth hormone deficiency (GHD); however, large-scale morphological brain networks (MBNs) undergo these patients remains unclear.

Objective: To investigate the topological organization of individual-level MBNs in pediatric GHD.

Methods: Sixty-one GHD and 42 typically developing controls (TDs) were enrolled. Inter-regional morphological similarity of GM was taken to construct individual-level MBNs. Between-group differences of topological parameters and network-based statistics analysis were compared. Finally, association relationship between network properties and clinical variables was analyzed.

Results: Compared to TDs, GHD indicated a disturbance in the normal small-world organization, reflected by increased L_p, γ, λ, σ and decreased C_p, E_glob (all P_FDR < 0.017). Regarding nodal properties, GHD exhibited increased nodal profiles at cerebellum 4-5, central executive network-related left inferior frontal gyrus, limbic regions-related right posterior cingulate gyrus, left hippocampus, and bilateral pallidum, thalamus (all P_FDR < 0.05). Meanwhile, GHD exhibited decreased nodal profiles at sensorimotor network -related bilateral paracentral lobule, default-mode network-related left superior frontal gyrus, visual network -related right lingual gyrus, auditory network-related right superior temporal gyrus and bilateral amygdala, right cerebellum 3, bilateral cerebellum 10, vermis 1-2, 3, 4-5, 6 (all P_FDR < 0.05). Furthermore, serum markers and behavior scores in GHD group were correlated with altered nodal profiles (P ≤ 0.046, uncorrected).

Conclusion: GHD undergo an extensive reorganization in large-scale individual-level MBNs, probably due to abnormal cortico-striatal-thalamo-cerebellum loops, cortico-limbic-cerebellum, dorsal visual-sensorimotor-striatal, and auditory-cerebellum circuitry. This study highlights the crucial role of abnormal morphological connectivity underlying GHD, which might result in their relatively slower development in motor, cognitive, and linguistic functional within behavior problem performance.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

生长激素缺乏症儿童个体层面形态相似性网络的改变。

背景：越来越多的证据表明，小儿生长激素缺乏症（GHD）患者的区域灰质（GM）形态发生了改变；然而，这些患者的大规模形态脑网络（MBNs）仍不清楚：研究小儿生长激素缺乏症患者个体水平的脑形态网络拓扑组织：方法：招募 61 名 GHD 和 42 名发育正常对照组（TDs）。采用GM的区域间形态相似性来构建个体水平的MBN。比较组间拓扑参数差异和基于网络的统计分析。最后，分析了网络特性与临床变量之间的关联关系：与 TD 相比，GHD 的正常小世界组织出现了紊乱，表现为 Lp、γ、λ、σ 增加，Cp、Eglob 减少（所有 PFDR 均小于 0.017）。在结节特性方面，GHD 在小脑 4-5、与中枢执行网络相关的左额叶下回、与边缘区域相关的右扣带回后部、左海马和双侧苍白球、丘脑的结节轮廓增加（PFDR 均< 0.05）。与此同时，GHD 在与感觉运动网络相关的双侧中央小叶旁、与默认模式网络相关的左侧额上回、与视觉网络相关的右侧舌回、与听觉网络相关的右侧颞上回和双侧杏仁核、右侧小脑 3、双侧小脑 10、蚓部 1-2、3、4-5、6（PFDR 均小于 0.05）等部位的结点轮廓均有所下降。此外，GHD组的血清标志物和行为评分与结节轮廓的改变相关（P≤0.046，未校正）：结论：GHD 患者的大规模个体水平 MBN 经历了广泛的重组，这可能是由于皮质-纹状体-唾液腺-小脑环路、皮质-边缘-小脑、背侧视觉-感觉运动-纹状体和听觉-小脑回路异常所致。这项研究强调了异常形态连接在 GHD 基础上的关键作用，这可能导致他们在行为问题表现中的运动、认知和语言功能发展相对较慢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Neurodevelopmental Disorders 医学-临床神经学

CiteScore

7.60

自引率

4.10%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Neurodevelopmental Disorders is an open access journal that integrates current, cutting-edge research across a number of disciplines, including neurobiology, genetics, cognitive neuroscience, psychiatry and psychology. The journal’s primary focus is on the pathogenesis of neurodevelopmental disorders including autism, fragile X syndrome, tuberous sclerosis, Turner Syndrome, 22q Deletion Syndrome, Prader-Willi and Angelman Syndrome, Williams syndrome, lysosomal storage diseases, dyslexia, specific language impairment and fetal alcohol syndrome. With the discovery of specific genes underlying neurodevelopmental syndromes, the emergence of powerful tools for studying neural circuitry, and the development of new approaches for exploring molecular mechanisms, interdisciplinary research on the pathogenesis of neurodevelopmental disorders is now increasingly common. Journal of Neurodevelopmental Disorders provides a unique venue for researchers interested in comparing and contrasting mechanisms and characteristics related to the pathogenesis of the full range of neurodevelopmental disorders, sharpening our understanding of the etiology and relevant phenotypes of each condition.