Sidonia and Nicu de Barcsy: a famous mother with post-partum hirsutism after giving birth to a famous son with idiopathic short stature.

IF 0.7 Q4 ENDOCRINOLOGY & METABOLISM Endocrinology, Diabetes and Metabolism Case Reports Pub Date : 2024-08-27 Print Date: 2024-07-01 DOI:10.1530/EDM-23-0095
Wouter W de Herder
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Abstract

Summary: At the end of the 19th century, an 18-year-old lady gave birth to a well-proportioned, though very small, son. After delivery, the mother developed a full-grown beard, whereas the son always remained of small stature. The mother developed diabetes mellitus and died, aged 59, from a complicated severe cold. The son died at the age of 91 because of chronic kidney disease. The differential diagnosis in the son is isolated growth hormone deficiency. The mother might have suffered luteoma of pregnancy, polycystic ovary syndrome (PCOS), or Sertoli-Leydig cell tumor(s). The two cases are apparently coincidental/not related in pathophysiology.

Learning points: Hirsutism occurring directly postpartum can have several causes. Patients with isolated growth hormone deficiency can live a long life without the substitution of growth hormone. Coincidence does not necessarily imply correlation. In the past, patients with endocrine disorders like severe hirsutism or small stature were employed at circuses and fairs to entertain the audience as curiosities.

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Sidonia 和 Nicu de Barcsy:一位著名的母亲在生下患有特发性身材矮小的儿子后,患上了产后多毛症。
摘要:19 世纪末,一位 18 岁的女士生下了一个身材匀称的儿子,虽然个头很小。分娩后,母亲长出了满脸的胡须,而儿子却始终身材矮小。母亲患上了糖尿病,59 岁时死于复杂的重感冒。儿子因慢性肾病去世,享年 91 岁。儿子的鉴别诊断是孤立性生长激素缺乏症。母亲可能患有妊娠黄体瘤、多囊卵巢综合症(PCOS)或 Sertoli-Leydig 细胞肿瘤。这两个病例在病理生理学上显然是巧合/无关:学习要点:产后直接出现多毛症可能有多种原因。孤立的生长激素缺乏症患者在不使用生长激素替代品的情况下也能长寿。巧合并不一定意味着相关。过去,患有严重多毛症或身材矮小等内分泌失调症的病人被马戏团和集市当作奇珍异宝供观众观赏。
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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
142
审稿时长
9 weeks
期刊介绍: Endocrinology, Diabetes & Metabolism Case Reports publishes case reports on common and rare conditions in all areas of clinical endocrinology, diabetes and metabolism. Articles should include clear learning points which readers can use to inform medical education or clinical practice. The types of cases of interest to Endocrinology, Diabetes & Metabolism Case Reports include: -Insight into disease pathogenesis or mechanism of therapy - Novel diagnostic procedure - Novel treatment - Unique/unexpected symptoms or presentations of a disease - New disease or syndrome: presentations/diagnosis/management - Unusual effects of medical treatment - Error in diagnosis/pitfalls and caveats
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