CHARACTERISTICS OF 'NOTCH' IN RETINOPATHY OF PREMATURITY FOLLOWING INTRAVITREAL RANIBIZUMAB MONOTHERAPY.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-23 DOI:10.1097/IAE.0000000000004231

Fengjun Zhang, Qiong Zou, Qiuping Liu, Zhipeng You

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Abstract

Purpose: To explore the clinical features and significance of "notch" in reactivation of retinopathy of prematurity (ROP) post-intravitreal ranibizumab (IVR) monotherapy.

Methods: Ninety-six infants (173 eyes) with type 1 or aggressive ROP (A-ROP) post-IVR monotherapy were retrospectively analyzed; 51 eyes were notch (+) and 122 eyes were notch (-). General demographics and clinical outcomes were compared by notch status for type 1 and A-ROP.

Results: The notch primarily appeared in stage 2 ROP (84.4 and 78.9%) at the junction of zones I and II (68.8 and 63.2%) on the temporal side in type 1 ROP and A-ROP. Notch was present in the type 1 ROP group before first IVR but post-treatment in the A-ROP group. A significantly higher reactivation rate, longer follow-up duration, and postmenstrual age at last follow-up were seen in the notch (+) versus the notch (-) group. In the notch (+) ROP group, the mean gestational age (28.34±0.93 vs. 29.94±1.48 weeks) was significantly lower in reactivated versus regressed eyes.

Conclusion: Notches appeared at different times but similar locations in type 1 ROP and A-ROP. The reactivation rate after IVR was increased in ROP with notches. Notch may be a useful biomarker for reactivation after IVR in ROP.

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玻璃体内雷尼珠单抗单药治疗早产儿视网膜病变的 "缺口 "特征。

目的：探讨 "切口 "在静脉注射雷尼珠单抗（IVR）后早产儿视网膜病变（ROP）再激活中的临床特征和意义：回顾性分析了96名接受IVR单药治疗后患有1型或侵袭性ROP（A-ROP）的婴儿（173只眼），其中51只眼有缺口（+），122只眼有缺口（-）。根据缺口状态比较了 1 型和 A-ROP 的一般人口统计学特征和临床结果：切迹主要出现在 ROP 2 期（84.4% 和 78.9%）的颞侧 I 区和 II 区交界处（68.8% 和 63.2%）。1 型 ROP 组在首次 IVR 之前就存在 Notch，而 A-ROP 组在治疗后才出现 Notch。切迹（+）组与切迹（-）组相比，再活率明显更高，随访时间更长，最后一次随访时的月经后年龄也更大。在切迹（+）ROP 组中，重新激活眼的平均胎龄（28.34±0.93 对 29.94±1.48 周）明显低于退化眼：结论：1 型 ROP 和 A 型 ROP 出现切迹的时间不同，但位置相似。有切迹的 ROP 在 IVR 后的再激活率增加。切迹可能是 ROP IVR 后再激活的有用生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.

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