Acyl-CoA Thioesterase 8 (ACOT8) is a Poor Prognostic Biomarker in Breast Cancer.

IF 1.8 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics & Personalized Medicine Pub Date : 2024-08-22 eCollection Date: 2024-01-01 DOI:10.2147/PGPM.S459762
Ziyun Wang, Hua Wang
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Abstract

Purpose: This study aimed to investigate the expression of Acyl-CoA thioesterase 8 (ACOT8) in breast cancer (BC) and its association with clinicopathological characteristics, patient survival, and immune infiltration.

Methods: We conducted a comprehensive analysis of ACOT8 mRNA differential expression across various cancer types, followed by survival analysis. We focused on BC, where ACOT8 expression was evaluated at both the mRNA and protein levels using online databases, qRT-PCR, and immunohistochemistry. Associations between ACOT8 expression and clinicopathological parameters were assessed using different databases. Additionally, we investigated the prognostic significance of ACOT8 in BC patients by analyzing various cohorts and databases. Furthermore, we predicted a potential signaling pathway and identified miR-1-3p as a possible upstream regulator of ACOT8. Finally, the relationship between ACOT8 and immune system infiltration, as well as immune checkpoint molecules, was examined.

Results: Our findings demonstrated upregulated ACOT8 mRNA and protein levels in BC. Elevated ACOT8 expression correlated positively with various clinicopathological characteristics, indicating an unfavorable prognosis for patients. Functional enrichment analysis suggested ACOT8 involvement in lipid metabolism, mitochondrial components, and ribosomal functions. Moreover, we identified connections between ACOT8 and immune system markers, immune cell infiltration, and immune checkpoints.

Conclusion: This study provides compelling evidence for ACOT8 upregulation in BC and its association with clinicopathological features and patient outcomes. Additionally, our findings suggest that targeting ACOT8 and immune checkpoints might enhance the effectiveness of immunotherapy in BC patients.

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Acyl-CoA Thioesterase 8 (ACOT8) 是乳腺癌的不良预后生物标志物。
目的:本研究旨在探讨乳腺癌(BC)中酰基-CoA硫代酯酶8(ACOT8)的表达及其与临床病理特征、患者生存和免疫浸润的关系:我们对各种癌症类型的 ACOT8 mRNA 差异表达进行了全面分析,然后进行了生存分析。我们重点研究了BC,利用在线数据库、qRT-PCR和免疫组化在mRNA和蛋白质水平评估了ACOT8的表达。我们使用不同的数据库评估了 ACOT8 表达与临床病理参数之间的关联。此外,我们还通过分析各种队列和数据库,研究了 ACOT8 在 BC 患者中的预后意义。此外,我们还预测了一条潜在的信号通路,并确定 miR-1-3p 可能是 ACOT8 的上游调节因子。最后,我们研究了ACOT8与免疫系统浸润以及免疫检查点分子之间的关系:我们的研究结果表明,ACOT8 mRNA和蛋白水平在BC中上调。ACOT8表达的升高与各种临床病理特征呈正相关,表明患者预后不良。功能富集分析表明,ACOT8 参与脂质代谢、线粒体成分和核糖体功能。此外,我们还发现了ACOT8与免疫系统标志物、免疫细胞浸润和免疫检查点之间的联系:本研究为 ACOT8 在 BC 中的上调及其与临床病理特征和患者预后的关系提供了有力的证据。此外,我们的研究结果表明,靶向 ACOT8 和免疫检查点可能会提高免疫疗法对 BC 患者的疗效。
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来源期刊
Pharmacogenomics & Personalized Medicine
Pharmacogenomics & Personalized Medicine Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
3.30
自引率
5.30%
发文量
110
审稿时长
16 weeks
期刊介绍: Pharmacogenomics and Personalized Medicine is an international, peer-reviewed, open-access journal characterizing the influence of genotype on pharmacology leading to the development of personalized treatment programs and individualized drug selection for improved safety, efficacy and sustainability. In particular, emphasis will be given to: Genomic and proteomic profiling Genetics and drug metabolism Targeted drug identification and discovery Optimizing drug selection & dosage based on patient''s genetic profile Drug related morbidity & mortality intervention Advanced disease screening and targeted therapeutic intervention Genetic based vaccine development Patient satisfaction and preference Health economic evaluations Practical and organizational issues in the development and implementation of personalized medicine programs.
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