Prognostic value of novel atherogenic indices in patients with acute myocardial infarction with and without type 2 diabetes

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Journal of diabetes and its complications Pub Date : 2024-08-24 DOI:10.1016/j.jdiacomp.2024.108850

Dominika Rokicka , Bartosz Hudzik , Marta Wróbel , Tomasz Stołtny , Dorota Stołtny , Alicja Nowowiejska-Wiewióra , Sonia Rokicka , Mariusz Gąsior , Krzysztof Strojek

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Abstract

Aims

Atherogenic indices: Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli's Risk Index I and II (CRI-I, CRI-II) are used in clinical studies as surrogates of major adverse cardiac and cerebrovascular events (MACCE). Risk prediction of MACCE in patients with acute myocardial infarction (AMI) has vital role in clinical practice. We aimed to assess prognostic value of these indices following AMI.

Methods

We analyzed patients with AMI with and without T2DM and the prognostic values of atherogenic indices for in-hospital death and MACCE within 12 months after AMI.

Results

Of 2461 patients, 152 in-hospital deaths (6.2 %) were reported (74 patients [7.4 %] with T2DM and 78 [5.3 %] without T2DM; p = 0.042). MACCE occurred in 22.7 % of patients (29.7 % with T2DM and 17.9 % without T2DM; p < 0.001). TG/HDL-C and AIP were higher in T2DM patients compared to those without T2DM (p < 0.001). Long-term MACCE was more prevalent in patients with T2DM (p < 0.001). The AUC-ROC for predicting in-hospital death based on TG/HDL-C and AIP was 0.57 (p = 0.002).

Conclusions

None of the atherogenic indices was an independent risk factor for in-hospital death or MACCE at 12-month follow-up in patients with AMI. AIP was an independent risk factor for death at 12-month follow-up.

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患有或未患有 2 型糖尿病的急性心肌梗死患者的新型致动脉粥样硬化指数的预后价值

目的致动脉粥样硬化指数：在临床研究中，甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值、血浆致动脉粥样硬化指数（AIP）、致动脉粥样硬化系数（AC）、卡斯泰利风险指数 I 和 II（CRI-I、CRI-II）被用作重大心脏和脑血管不良事件（MACCE）的替代指标。对急性心肌梗死（AMI）患者的主要不良心脑血管事件进行风险预测在临床实践中具有重要作用。我们分析了有 T2DM 和无 T2DM 的急性心肌梗死患者，以及动脉粥样硬化指数对急性心肌梗死后 12 个月内院内死亡和 MACCE 的预后价值。结果在 2461 名患者中，有 152 人（6.2%）在院内死亡（74 名患者[7.4%]有 T2DM，78 名患者[5.3%]无 T2DM；P = 0.042）。22.7%的患者发生了 MACCE（T2DM 患者为 29.7%，非 T2DM 患者为 17.9%；P = 0.001）。与非 T2DM 患者相比，T2DM 患者的 TG/HDL-C 和 AIP 更高（p <0.001）。T2DM 患者的长期澳门巴黎人娱乐官网发生率更高（p < 0.001）。结论在随访 12 个月的 AMI 患者中，没有一个致动脉粥样硬化指数是院内死亡或 MACCE 的独立危险因素。AIP是随访12个月时死亡的独立风险因素。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.