Confinement Effect Enhanced Bipolar Electrochemistry: Structural Color Coding Coupled with Wireless Electrochemiluminescence Imaging Technology.

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL Analytical Chemistry Pub Date : 2024-09-10 Epub Date: 2024-08-27 DOI:10.1021/acs.analchem.4c01094

Xiao-Yan Wang, Sheng-Tong Wu, Yi-Zhi Lin, Shou-Nian Ding, Jing-Juan Xu, Hong-Yuan Chen

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Abstract

In this work, SiO₂/CNTs photonic crystal beads were constructed by doping CNTs into SiO₂ photonic crystals, which have an angle-independent responsive structural color and can be used as bipolar electrodes due to their good electrical conductivity. In addition, the bipolar electrode-electrochemiluminescence (BPE-ECL) experiments and finite element simulation prove that the low driving voltage can trigger the bipolar electrode electrochemical reactions by confinement effect. Inspired by this, it is the first to combine the SiO₂/CNTs structural color coding scheme with low-drive voltage induced wireless BPE-ECL imaging based on the confinement effect of microchannels to achieve simultaneous immune detection of ovarian cancer biomarkers (CA125, CEA, AFP). The detection limits of successfully constructed high-throughput BPE-ECL biosensor for AFP, CEA, and CA125 are 0.72 ng/mL, 0.95 ng/mL, and 1.03 U/mL, respectively, and have good stability and specificity, which expands the application of electrochemiluminescence and lays a foundation for the development of electrochemiluminescence coding technology.

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约束效应增强型双极电化学：结构颜色编码与无线电化学发光成像技术。

本研究通过在SiO2光子晶体中掺杂CNTs构建了SiO2/CNTs光子晶体珠，其具有与角度无关的响应结构颜色，并因其良好的导电性可用作双极电极。此外，双极性电极电化学发光（BPE-ECL）实验和有限元模拟证明，低驱动电压可通过限制效应触发双极性电极电化学反应。受此启发，该研究首次将 SiO2/CNTs 结构颜色编码方案与基于微通道禁锢效应的低驱动电压诱导无线 BPE-ECL 成像相结合，实现了卵巢癌生物标志物（CA125、CEA、AFP）的同步免疫检测。成功构建的高通量BPE-ECL生物传感器对AFP、CEA和CA125的检测限分别为0.72 ng/mL、0.95 ng/mL和1.03 U/mL，具有良好的稳定性和特异性，拓展了电化学发光的应用领域，为电化学发光编码技术的发展奠定了基础。

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.