Mapping sagittal-plane reference brain atlas of the cynomolgus macaque (Macaca fascicularis) based on consecutive cytoarchitectonic images.

IF 2.7 3区医学 Q1 ANATOMY & MORPHOLOGY Brain Structure & Function Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI:10.1007/s00429-024-02851-y

Yue Luo, Xiangning Li, Can Zhou, Guangcai Liu, Xueyan Jia, Xiaoquan Yang, Anan Li, Hui Gong, Zhao Feng

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Abstract

The brain atlas is essential for exploring the anatomical structure and function of the brain. Non-human primates, such as cynomolgus macaque, have received increasing attention due to their genetic similarity to humans. However, current macaque brain atlases only offer coarse sections with intervals along the coronal direction, failing to meet the needs of single-cell resolution studies in functional and multi-omics research of the macaque brain. To address this issue, we utilized fluorescence micro-optical sectioning tomography to obtain sub-micron resolution cytoarchitectonic images of the macaque brain at the sagittal plane. Based on the obtained 8000 image sequences, a reference brain atlas comprising 45 sagittal sections was created, delineating 270 brain regions other than the cortex. Additionally, a website was established to share the reference atlas corresponding image data. This study is expected to provide an essential dataset and tool for scientists studying the macaque brain.

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根据连续的细胞结构图像绘制猕猴（Macaca fascicularis）矢状面参考脑图谱。

脑图谱对于探索大脑的解剖结构和功能至关重要。非人类灵长类动物，如猕猴，因其基因与人类相似而受到越来越多的关注。然而，目前的猕猴脑图谱只能提供沿冠状方向间隔的粗切片，无法满足猕猴脑功能和多组学研究中单细胞分辨率研究的需要。针对这一问题，我们利用荧光微光学切片断层扫描技术获得了矢状面亚微米分辨率的猕猴脑细胞结构图像。根据获得的 8000 个图像序列，我们绘制了由 45 个矢状切面组成的参考脑图集，划分了除皮层以外的 270 个脑区。此外，还建立了一个网站来共享参考图集的相应图像数据。这项研究有望为研究猕猴大脑的科学家提供一个重要的数据集和工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Structure & Function 医学-解剖学与形态学

CiteScore

6.00

自引率

6.50%

发文量

168

审稿时长

8 months

期刊介绍： Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.