Advances in understanding the immunity of the brain and its borders: Focus on brain macrophages

IF 7.9 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Translational Medicine Pub Date : 2024-08-27 DOI:10.1002/ctm2.70014

Patrick Süß, Martin Diebold, Roman Sankowski

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Abstract

A recent study outlines the phenotypes of brain border region macrophages in developing, normal and glioblastoma-affected brains. For the first time, the authors show in-vivo turnover of human brain border macrophages. The findings have implications for the understanding of brain border immunity and potential macrophage targeting therapies.

keypoints

Human border region macrophages are distinct from microglia.
These distinct phenotypes are established early during embryonal development - Brain border macrophages are partially replaced by bone marrow-derived myeloid cells.
The transcriptional phenotypes of glioblastoma-associated macrophage are determined by the anatomical region.

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了解大脑及其边界免疫的进展：聚焦脑巨噬细胞。

最近的一项研究概述了发育中、正常和受胶质母细胞瘤影响的大脑中脑边界区域巨噬细胞的表型。作者首次在体内展示了人类脑边界巨噬细胞的更替。这些发现对了解脑边界免疫和潜在的巨噬细胞靶向疗法具有重要意义。要点：人类边界区域巨噬细胞与小胶质细胞不同。这些不同的表型在胚胎发育早期就已确立--脑边界巨噬细胞部分被骨髓来源的髓样细胞取代。胶质母细胞瘤相关巨噬细胞的转录表型由解剖区域决定。

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来源期刊

Clinical and Translational Medicine Multiple-

CiteScore

15.90

自引率

1.90%

发文量

450

审稿时长

4 weeks

期刊介绍： Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.