Evaluation of the Potential Clinical Utility of Maternal Serum Biomarkers for Risk Assessment in Gestational Diabetes.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2024-08-01 DOI:10.7754/Clin.Lab.2024.240208

Weaam Gouda, Lamiaa Mageed, Ahmed Okasha, Mie Afify

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Abstract

Background: The exact relationships of circulating fibronectin, SHBG, and ILGF-1 with T2DM and GDM remain inconsistent. Therefore, in this study we evaluate their associations in T2DM and GDM. Additionally, we evaluate their correlations with different biochemical parameters.

Methods: A total of 505 pregnant women (180 with T2DM, 160 GDM patients, and 165 controls) were enrolled in the current study. SHBG, ILGF-1, and fibronectin were estimated by using the ELISA technique.

Results: The GDM and T2DM groups had higher ILGF-1 and fibronectin levels than the control group, while having a lower SHGB level. The correlations of clinical characteristics with ILGF-1, SHBG, and fibronectin showed that ILGF-1 in GDM patients was positively associated with HbA1c% and insulin. T2DM was positively related to insulin and insulin resistance, as well. There was a positive association between SHBG and insulin among the T2DM groups. Furthermore, in T2DM individuals, fibronectin was positively related with HbA1c% and glucose.

Conclusions: The study suggests that the circulating levels of fibronectin, SHBG, and ILGF-1 are linked to GDM and T2DM risk. Hence, the circulating concentrations of these biomarkers are potentially useful for predicting the risk of GDM as well as developing T2DM.

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评估母体血清生物标记物在妊娠糖尿病风险评估中的潜在临床实用性。

背景：循环纤连蛋白、SHBG 和 ILGF-1 与 T2DM 和 GDM 的确切关系仍不一致。因此，在本研究中，我们评估了它们与 T2DM 和 GDM 的关系。此外，我们还评估了它们与不同生化指标的相关性：本研究共招募了 505 名孕妇（180 名 T2DM 患者、160 名 GDM 患者和 165 名对照组）。结果：GDM组和T2DM组孕妇的SHBG、ILGF-1和纤连蛋白均高于对照组：结果：与对照组相比，GDM 组和 T2DM 组的 ILGF-1 和纤连蛋白水平较高，而 SHGB 水平较低。临床特征与 ILGF-1、SHGBG 和纤连蛋白的相关性显示，GDM 患者的 ILGF-1 与 HbA1c% 和胰岛素呈正相关。T2DM 与胰岛素和胰岛素抵抗也呈正相关。在 T2DM 组别中，SHBG 与胰岛素呈正相关。此外，在 T2DM 患者中，纤连蛋白与 HbA1c% 和血糖呈正相关：研究表明，循环中的纤维粘连蛋白、SHBG 和 ILGF-1 水平与 GDM 和 T2DM 风险有关。因此，这些生物标志物的循环浓度可能有助于预测 GDM 和 T2DM 的发病风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.