Recent developments in molecular targeted therapies for hepatocellular carcinoma in the genomic era.

IF 3.9 3区 医学 Q1 PATHOLOGY Expert Review of Molecular Diagnostics Pub Date : 2024-09-01 Epub Date: 2024-08-28 DOI:10.1080/14737159.2024.2392278
Ugo Testa
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Abstract

Introduction: Primary liver cancer is a major health problem being the sixth most frequent cancer in the world and the third cause of cancer-related death in the world. The most common histological type of liver cancer is hepatocellular carcinoma (HCC, 75-80%).

Areas covered: Based on primary literature, this review provides an updated analysis of studies of genetic characterization of HCC at the level of gene mutation profiling, copy number alterations, and gene expression, with the definition of molecular subgroups and the identification of some molecular biomarkers and therapeutic targets. Recent therapeutic developments are also highlighted.

Expert opinion: Deepening the understanding of the molecular complexity of HCC is progressively paving the way for the development of more personalized treatment approaches. Two important strategies involve the definition and validation of molecularly defined therapeutic targets in a subset of HCC patients and the identification of suitable biomarkers for approved systematic therapies (multikinase inhibitors and immunotherapies). The extensive molecular characterization of patients at the genomic and transcriptomic levels and the inclusion of detailed and relevant translational studies in clinical trials will represent a fundamental tool for improving the benefit of systemic therapies in HCC.

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基因组时代肝细胞癌分子靶向疗法的最新发展。
简介原发性肝癌是一个重大的健康问题,是世界上第六大最常见的癌症,也是世界上第三大与癌症相关的死亡原因。肝癌最常见的组织学类型是肝细胞癌(HCC,75-80%):本综述以主要文献为基础,从基因突变剖析、拷贝数改变和基因表达等层面对HCC的遗传特征研究进行了最新分析,并对分子亚组进行了定义,确定了一些分子生物标志物和治疗靶点。此外,还重点介绍了最新的治疗进展:加深对 HCC 分子复杂性的了解正在逐步为开发更个性化的治疗方法铺平道路。两个重要的战略涉及在HCC患者中定义和验证分子定义的治疗靶点,以及为已获批准的系统疗法(多激酶抑制剂和免疫疗法)确定合适的生物标志物。在基因组和转录组水平上对患者进行广泛的分子特征描述,并在临床试验中纳入详细的相关转化研究,将成为提高 HCC 全身疗法疗效的基本工具。
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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
71
审稿时长
1 months
期刊介绍: Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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