Rehabilitation Intervention Is Associated With Improved Neurodevelopment and Modulation of Inflammatory Molecules in Children With Cerebral Palsy.

IF 2 4区医学 Q3 CLINICAL NEUROLOGY Journal of Child Neurology Pub Date : 2024-08-01 Epub Date: 2024-08-28 DOI:10.1177/08830738241273436

Rafael Coelho Magalhães, Roberta da Silva Filha, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira, Janaina Matos Moreira, Ana Cristina Simões E Silva

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Abstract

Aim: To evaluate the effects of systematic rehabilitation on both the neuropsychomotor development, and on the peripheral response from immunological and neuroplastic mediators in children with cerebral palsy.

Methods: This is a prospective cohort study with 90 children with cerebral palsy at 18 months of age. Sixty children received rehabilitation for 6 months, and they were compared to 30 children that were placed in the waiting list. Peripheral biomarkers and neuropsychomotor parameters were compared between the Rehab vs the Nonrehab groups at baseline and at 6 months.

Results: Results showed higher Bayley III scores in the Rehab group, with significant differences in inflammatory and neurotrophic biomarkers between groups. Rehabilitation was associated to decreased levels of IL-12p70, IL-6, IL-1β, CXCL8 IL-8, and CXCL9/MIG and increased levels of BDNF and GDNF. Nonrehab children had stable immune molecule levels but decreased BDNF levels over time.

Conclusion: Rehabilitation improved neurodevelopment parameters and modulated levels of inflammatory (↓) and neurotrophic (↑) biomarkers.

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康复干预与脑瘫儿童神经发育的改善和炎症分子的调节有关。

目的：评估系统康复对脑瘫儿童神经心理运动发育以及免疫和神经可塑性介质外周反应的影响：这是一项前瞻性队列研究，研究对象为 90 名 18 个月大的脑瘫儿童。60名儿童接受了为期6个月的康复治疗，并与30名候补儿童进行了比较。比较了康复组和非康复组在基线和 6 个月时的外周生物标志物和神经心理运动参数：结果显示，康复组的 Bayley III 得分更高，各组之间的炎症和神经营养生物标志物存在显著差异。康复治疗与 IL-12p70、IL-6、IL-1β、CXCL8 IL-8 和 CXCL9/MIG 水平的降低以及 BDNF 和 GDNF 水平的升高有关。非康复儿童的免疫分子水平稳定，但随着时间的推移，BDNF水平下降：康复治疗改善了神经发育参数，调节了炎症（↓）和神经营养（↑）生物标志物的水平。

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来源期刊

Journal of Child Neurology 医学-临床神经学

CiteScore

4.20

自引率

5.30%

发文量

111

审稿时长

3-6 weeks

期刊介绍： The Journal of Child Neurology (JCN) embraces peer-reviewed clinical and investigative studies from a wide-variety of neuroscience disciplines. Focusing on the needs of neurologic patients from birth to age 18 years, JCN covers topics ranging from assessment of new and changing therapies and procedures; diagnosis, evaluation, and management of neurologic, neuropsychiatric, and neurodevelopmental disorders; and pathophysiology of central nervous system diseases.