Advancements in Nanoporous Materials for Biomedical Imaging and Diagnostics.

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-08-14 DOI:10.3390/jfb15080226
Nargish Parvin, Vineet Kumar, Tapas Kumar Mandal, Sang Woo Joo
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Abstract

This review explores the latest advancements in nanoporous materials and their applications in biomedical imaging and diagnostics. Nanoporous materials possess unique structural features, including high surface area, tunable pore size, and versatile surface chemistry, making them highly promising platforms for a range of biomedical applications. This review begins by providing an overview of the various types of nanoporous materials, including mesoporous silica nanoparticles, metal-organic frameworks, carbon-based materials, and nanoporous gold. The synthesis method for each material, their current research trends, and prospects are discussed in detail. Furthermore, this review delves into the functionalization and surface modification techniques employed to tailor nanoporous materials for specific biomedical imaging applications. This section covers chemical functionalization, bioconjugation strategies, and surface coating and encapsulation methods. Additionally, this review examines the diverse biomedical imaging techniques enabled by nanoporous materials, such as fluorescence imaging, magnetic resonance imaging (MRI), computed tomography (CT) imaging, ultrasound imaging, and multimodal imaging. The mechanisms underlying these imaging techniques, their diagnostic applications, and their efficacy in clinical settings are thoroughly explored. Through an extensive analysis of recent research findings and emerging trends, this review underscores the transformative potential of nanoporous materials in advancing biomedical imaging and diagnostics. The integration of interdisciplinary approaches, innovative synthesis techniques, and functionalization strategies offers promising avenues for the development of next-generation imaging agents and diagnostic tools with enhanced sensitivity, specificity, and biocompatibility.

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用于生物医学成像和诊断的纳米多孔材料的进展。
这篇综述探讨了纳米多孔材料的最新进展及其在生物医学成像和诊断中的应用。纳米多孔材料具有独特的结构特征,包括高比表面积、可调孔径和多变的表面化学性质,使它们成为极具潜力的生物医学应用平台。本综述首先概述了各种类型的纳米多孔材料,包括介孔二氧化硅纳米颗粒、金属有机框架、碳基材料和纳米多孔金。详细讨论了每种材料的合成方法、当前的研究趋势和前景。此外,本综述还深入探讨了为特定生物医学成像应用定制纳米多孔材料所采用的功能化和表面改性技术。这一部分涵盖了化学功能化、生物共轭策略以及表面涂层和封装方法。此外,本综述还探讨了利用纳米多孔材料实现的各种生物医学成像技术,如荧光成像、磁共振成像(MRI)、计算机断层扫描(CT)成像、超声成像和多模态成像。该书深入探讨了这些成像技术的内在机制、诊断应用及其在临床环境中的功效。通过对最新研究成果和新兴趋势的广泛分析,本综述强调了纳米多孔材料在推动生物医学成像和诊断方面的变革潜力。跨学科方法、创新合成技术和功能化策略的整合为开发具有更高灵敏度、特异性和生物兼容性的下一代成像剂和诊断工具提供了广阔的前景。
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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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