Effects of transcranial magnetic stimulation on axonal regeneration in the corticospinal tract of female rats with spinal cord injury

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS Journal of Neuroscience Methods Pub Date : 2024-08-25 DOI:10.1016/j.jneumeth.2024.110267

Mengxuan Hu , Zewen Tang , Huijun Li , Qian Lei , Qingqin Xu , Junhong Su , Ying Huang , Shi Chen , Hemu Chen

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Abstract

Background

This study investigates the potential of transcranial magnetic stimulation (TMS) to enhance spinal cord axon regeneration by modulating corticospinal pathways and improving motor nerve function recovery in rats with spinal cord injury (SCI).

New method

TMS is a non-invasive neuromodulation technique that generates a magnetic field to activate neurons in the brain, leading to depolarization and modulation of cortical activity. Initially utilized for brain physiology research, TMS has evolved into a diagnostic and prognostic tool in clinical settings, with increasing interest in its therapeutic applications. However, its potential for treating motor dysfunction in SCI has been underexplored.

Results

The TMS intervention group exhibited significant improvements compared to the control group across behavioral assessments, neurophysiological measurements, pathological analysis, and immunological markers.

Comparison with existing methods

Unlike most studies that focus on localized spinal cord injury or muscle treatments, this study leverages the non-invasive, painless, and highly penetrating nature of TMS to focus on the corticospinal tracts, exploring its therapeutic potential for SCI.

Conclusions

TMS enhances motor function recovery in rats with SCI by restoring corticospinal pathway integrity and promoting axonal regeneration. These findings highlight TMS as a promising therapeutic option for SCI patients with currently limited treatment alternatives.

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经颅磁刺激对脊髓损伤雌性大鼠皮质脊髓束轴突再生的影响

背景：本研究探讨了经颅磁刺激（TMS）通过调节皮质脊髓通路促进脊髓轴突再生和改善脊髓损伤（SCI）大鼠运动神经功能恢复的潜力：经颅磁刺激是一种非侵入性神经调控技术，通过产生磁场激活大脑中的神经元，从而导致去极化并调节大脑皮层的活动。TMS 最初用于脑生理学研究，现已发展成为临床诊断和预后工具，其治疗应用也越来越受到关注。然而，它在治疗 SCI 运动功能障碍方面的潜力尚未得到充分开发：结果：与对照组相比，TMS干预组在行为评估、神经电生理测量、病理分析和免疫标记物方面均有明显改善：与大多数侧重于局部脊髓损伤或肌肉治疗的研究不同，本研究利用 TMS 的无创、无痛和高穿透性特点，将重点放在皮质脊髓束上，探索其对 SCI 的治疗潜力：结论：通过恢复皮质脊髓通路的完整性和促进轴突再生，TMS 可增强 SCI 大鼠的运动功能恢复。这些研究结果表明，对于目前治疗手段有限的 SCI 患者来说，TMS 是一种很有前景的治疗选择。

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.