The causal relationship between immune cells and atopic dermatitis: A bidirectional Mendelian randomization study.

IF 2 4区医学 Q3 DERMATOLOGY Skin Research and Technology Pub Date : 2024-09-01 DOI:10.1111/srt.13858

Xu Zhu, Wenzhong Wu

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Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition whose origins remain unclear. Existing epidemiological evidence suggests that inflammation and immune factors play pivotal roles in the onset and progression of AD. However, previous research on the connection between immune inflammation and AD has yielded inconclusive results.

Methods: To evaluate the causal relationship between immunological characteristics and AD, this study employed a bidirectional, two-sample Mendelian randomization (MR) approach. We utilized large-scale, publicly available genome-wide association studies to investigate the causal associations between 731 immunological feature cells and the risk of AD.

Results: Significant associations were identified between six immune phenotypes and AD risk: increased Basophil %CD33dim HLA DR-CD66b-, CD25 on IgD+ CD24+, CD40 on monocytes, HLA DR on CD14+ CD16-monocytes, HLA DR on CD14+monocytes correlated with higher AD risk, while elevated CD3 on CD4 Treg was linked to lower risk. Reverse MR analysis revealed AD as a risk factor for IgD+ CD38br AC and IgD+ CD38br %B cell, but a protective factor against CD20 on IgD+ CD38- naive and CD8 on NKT.

Conclusion: Our findings elucidate the intricate interplay between immune cells and AD, informing future research into AD pathophysiology and therapeutics.

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免疫细胞与特应性皮炎之间的因果关系：孟德尔随机双向研究

背景：特应性皮炎（AD）是一种慢性炎症性皮肤病，其发病原因尚不清楚。现有的流行病学证据表明，炎症和免疫因素在特应性皮炎的发病和发展过程中起着关键作用。然而，以往关于免疫炎症与 AD 之间关系的研究并没有得出结论：为了评估免疫特征与 AD 之间的因果关系，本研究采用了双向、双样本孟德尔随机化（MR）方法。我们利用大规模、公开的全基因组关联研究，调查了 731 个免疫特征细胞与 AD 风险之间的因果关系：结果：发现了六种免疫表型与AD风险之间的显著关联：嗜碱性粒细胞%CD33dim HLA DR-CD66b-、IgD+ CD24+上的CD25、单核细胞上的CD40、CD14+ CD16-单核细胞上的HLA DR、CD14+单核细胞上的HLA DR增加与AD风险升高相关，而CD4 Treg上的CD3升高与风险降低相关。反向MR分析显示，AD是IgD+ CD38br AC和IgD+ CD38br %B细胞的风险因素，但却是IgD+ CD38- naive的CD20和NKT的CD8的保护因素：我们的研究结果阐明了免疫细胞与AD之间错综复杂的相互作用，为今后的AD病理生理学和治疗学研究提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.