[Pathological Complete Response to Neoadjuvant Chemotherapy for Abscess-Forming Rectal Cancer-A Case Report].

Q4 Medicine Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-08-01
Kenji Namiki, Yoshinori Iwata, Shuji Komori, Chihiro Tanaka, Narutoshi Nagao, Masahiko Kawai
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Abstract

We report a case of pathological complete response to neoadjuvant chemotherapy for abscess-forming rectal cancer. A woman in her 60s visited her primary care physician because she noticed an increase in the quantity of vaginal discharge. An irregular mass of goose-egg size found on the right vaginal wall was diagnosed as adenocarcinoma on biopsy, and she was referred to our hospital. After further examination, the mass was diagnosed as RbP, cT4b(vaginal), cN1a, cM0, cStage Ⅲc rectal cancer with abscess formation. After 6 courses of CAPOX as neoadjuvant chemotherapy, rectal resection(combined resection of the posterior vaginal wall) was performed. Pathological diagnosis showed no tumor cells and lymph node metastasis. Four courses of CAPOX were administered as postoperative adjuvant chemotherapy. The patient is still alive 4 years after surgery, without recurrence. When neoadjuvant chemotherapy is successful, radical resection is possible, even in cases with abscess formation, and long-term survival can be expected.

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[脓肿型直肠癌对新辅助化疗的病理完全反应--病例报告]。
我们报告了一例脓肿型直肠癌新辅助化疗病理完全反应病例。一位 60 多岁的妇女因发现阴道分泌物增多而就诊于主治医生。在右侧阴道壁上发现了一个鹅蛋大小的不规则肿块,活检后诊断为腺癌,于是她被转诊到我院。经进一步检查,肿块被诊断为 RbP、cT4b(阴道)、cN1a、cM0、c Ⅲc 期直肠癌,伴脓肿形成。经过 6 个疗程的 CAPOX 新辅助化疗后,患者接受了直肠切除术(阴道后壁联合切除术)。病理诊断显示无肿瘤细胞和淋巴结转移。术后进行了四个疗程的 CAPOX 辅助化疗。患者术后 4 年仍然存活,没有复发。如果新辅助化疗成功,即使有脓肿形成的病例也有可能进行根治性切除,并有望获得长期生存。
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