Mai S Attia, Fadwa Ayman, Mohamed S Attia, Galal Yahya, Mansour H Zahra, Magdi Mohamed Ibrahim Khalil, Abdel Aziz A Diab
{"title":"Mitigating diabetes-related complications: Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats.","authors":"Mai S Attia, Fadwa Ayman, Mohamed S Attia, Galal Yahya, Mansour H Zahra, Magdi Mohamed Ibrahim Khalil, Abdel Aziz A Diab","doi":"10.4239/wjd.v15.i8.1778","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes is one of the most prevalent chronic diseases worldwide, significantly impacting patients' quality of life. Current treatment options like metformin (MET) effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy, neuropathy, nephropathy, hepatopathy, and cardiovascular diseases.</p><p><strong>Aim: </strong>To propose the supplementation of cholecalciferol (CHO) and taurine (TAU) to enhance MET efficacy in controlling diabetes while minimizing the risk of associated complications.</p><p><strong>Methods: </strong>The study involved sixty rats, including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by streptozotocin. The experimental rats were further subdivided into positive control and treatment subgroups. The four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either CHO, TAU, or both.</p><p><strong>Results: </strong>Diabetic rats exhibited elevated levels of glucose, insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), glycated hemoglobin%, lipid markers, aspartate aminotransferase, and malondialdehyde, along with reduced levels of antioxidant enzymes (catalase and superoxide dismutase). The administration of CHO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet mass. The antioxidative, anti-inflammatory, and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned abnormalities.</p><p><strong>Conclusion: </strong>The supplementation of CHO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative, anti-inflammatory, and anti-apoptotic effects.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"15 8","pages":"1778-1792"},"PeriodicalIF":4.2000,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346095/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Diabetes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4239/wjd.v15.i8.1778","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Type 2 diabetes is one of the most prevalent chronic diseases worldwide, significantly impacting patients' quality of life. Current treatment options like metformin (MET) effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy, neuropathy, nephropathy, hepatopathy, and cardiovascular diseases.
Aim: To propose the supplementation of cholecalciferol (CHO) and taurine (TAU) to enhance MET efficacy in controlling diabetes while minimizing the risk of associated complications.
Methods: The study involved sixty rats, including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by streptozotocin. The experimental rats were further subdivided into positive control and treatment subgroups. The four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either CHO, TAU, or both.
Results: Diabetic rats exhibited elevated levels of glucose, insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), glycated hemoglobin%, lipid markers, aspartate aminotransferase, and malondialdehyde, along with reduced levels of antioxidant enzymes (catalase and superoxide dismutase). The administration of CHO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet mass. The antioxidative, anti-inflammatory, and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned abnormalities.
Conclusion: The supplementation of CHO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative, anti-inflammatory, and anti-apoptotic effects.
背景：2 型糖尿病是全球最普遍的慢性疾病之一，严重影响患者的生活质量。目的：提出补充胆钙化醇（CHO）和牛磺酸（TAU）以增强二甲双胍控制糖尿病的疗效，同时将相关并发症的风险降至最低：研究涉及 60 只大鼠，包括 10 只非糖尿病对照组大鼠和 50 只由链脲佐菌素诱导的 2 型糖尿病实验组大鼠。实验鼠又分为阳性对照组和治疗组。四个治疗组被随机分配到单一的 MET 治疗或 MET 与 CHO、TAU 或两者的补充剂相结合的治疗组：结果：糖尿病大鼠的血糖、胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）、糖化血红蛋白%、血脂指标、天冬氨酸氨基转移酶和丙二醛水平升高，抗氧化酶（过氧化氢酶和超氧化物歧化酶）水平降低。糖尿病大鼠在服用 MET 的同时服用 CHO 和 TAU 补充剂，可明显恢复胰岛质量。建议的联合疗法的抗氧化、抗炎和抗凋亡特性显著改善了上述异常情况：结论：通过抗氧化、抗炎和抗细胞凋亡作用补充 CHO 和 TAU 以及 MET，可明显改善代谢参数并预防糖尿病并发症。
期刊介绍：
The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
