Serum fibrinogen/albumin ratio and early neurological deterioration in patients with recent small subcortical infarction.

Annals of medicine Pub Date : 2024-12-01 Epub Date: 2024-08-28 DOI:10.1080/07853890.2024.2396072
Haixu Zhao, Ying Yao, Ce Zong, Hongbing Liu, Ke Zhang, Yuan Song, Beizhu Ye, Jing Yang, Yusheng Li, Bo Song, Yuming Xu, Yuan Gao
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Abstract

Background: Serum fibrinogen/albumin ratio (FAR) is a new inflammatory marker related to a variety of diseases, and it has been shown to be associated with stroke. This study is to investigate the relationship between serum FAR and early neurological deterioration (END) in patients with recent small subcortical infarction (RSSI).

Patients and methods: Consecutive RSSI patients admitted to the First Affiliated Hospital of Zhengzhou University from June 2015 to June 2022 were enrolled. The National Institute of Health Stroke Scale (NIHSS) was utilized to evaluate the severity of the patients at admission and within seven days post-admission. END was defined as an increase of ≥2 points in NIHSS score from admission or ≥1 point in the motor item of the score within seven days post-admission. Multivariate logistic regression analysis was employed to identify risk factors for END. The correlation between FAR and END was investigated using restricted cubic spline (RCS) analysis. Subgroup analysis was used to assess stability across different populations.

Results: A total of 766 RSSI patients were included in the analysis, with 538 males (70.24%). END occurred in 115 (15.01%) patients. Multivariate logistic regression analysis revealed that FAR (OR = 1.016, 95%CI: 1.005-1.028), PAD (OR = 1.805, 95%CI: 1.161-2.807) and age (OR = 1.028, 95%CI: 1.009-1.048) were associated with END in RSSI patients. RCS analysis indicated a linear correlation between FAR and END (p for nonlinear = .128). Subgroup analysis indicated association between FAR and END in male (OR = 1.02, 95%CI: 1.00-1.03), patients aged ≤65 years (OR = 1.02, 95%CI: 1.00-1.03) and patients without smoking history (OR = 1.02, 95%CI: 1.00-1.03).

Conclusions: Elevated FAR levels were associated with the occurrence of END within seven days after admission in RSSI patients, especially in men, age ≤65 years, or patients without smoking history.

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血清纤维蛋白原/白蛋白比值与近期小型皮层下脑梗塞患者的早期神经功能恶化。
背景:血清纤维蛋白原/白蛋白比值(FAR)是一种与多种疾病相关的新型炎症标志物,已被证实与脑卒中有关。本研究旨在探讨近期皮层下小梗死(RSSI)患者血清 FAR 与早期神经功能恶化(END)之间的关系:2015年6月至2022年6月郑州大学第一附属医院收治的连续RSSI患者。采用美国国立卫生研究院卒中量表(NIHSS)评估患者入院时和入院后七天内的严重程度。END的定义是入院时NIHSS评分比入院时增加≥2分,或入院后七天内运动项目评分增加≥1分。采用多变量逻辑回归分析确定END的风险因素。采用受限立方样条曲线(RCS)分析法研究了FAR和END之间的相关性。亚组分析用于评估不同人群的稳定性:共有 766 名 RSSI 患者参与分析,其中男性 538 人(70.24%)。115名患者(15.01%)发生了END。多变量逻辑回归分析显示,FAR(OR = 1.016,95%CI:1.005-1.028)、PAD(OR = 1.805,95%CI:1.161-2.807)和年龄(OR = 1.028,95%CI:1.009-1.048)与 RSSI 患者的END有关。RCS 分析表明,FAR 与END 呈线性相关(非线性 p = .128)。亚组分析表明,男性(OR = 1.02,95%CI:1.00-1.03)、年龄小于 65 岁的患者(OR = 1.02,95%CI:1.00-1.03)和无吸烟史的患者(OR = 1.02,95%CI:1.00-1.03)的 FAR 与END 相关:结论:FAR水平升高与RSSI患者入院后7天内发生END有关,尤其是男性、年龄≤65岁或无吸烟史的患者。
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