Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity

Food chemistry advances Pub Date : 2024-08-26 DOI:10.1016/j.focha.2024.100794

Joel Okpoghono , Busade Adebayo Agbetuyi , Toritseju Eyide , Innocent Onyesom

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Abstract

The present study investigated the defensive effect of kaempferol in the tissues of Wistar rats fed with vacuum gas oil polluted garri diet. The rats (30) were grouped into six (n = 5): Group 1: Control: Fried garri normal diet (FGND). Group 2 and 3 were given FGND and treated with 50 and 100 mg/kg b. wt of kaempferol. Group 4: Fried garri diet with vacuum gas oil (FGD-VGO) only. Group 5 and 6 were given FGD-VGO then treated with 50 and 100 mg/kg b. wt. of kaempferol. The rats were euthanized using carbon dioxide after experimental period of 28 days. The tissues (kidney and brain) were excised for biochemical assays. The results indicated a significant decrease in antioxidant markers (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-s-transferase, GST), Na⁺/K⁺-ATPase, percentage of fragmented deoxyribonucleic acid (DNA) and increase malondialdehyde (MDA) in the tissues of rats in group 4 compared to the other groups. However, treatment with kaempferol significantly decreased MDA level and increased antioxidant markers in the tissues of rats fed FGD-VGO. In conclusion, the data obtained may point out to kaempferol playing a crucial role as an antioxidant against garri meal tainted with vacuum gas oil in Wistar rats.

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山奈酚对掺有真空瓦斯油的嘎啦粉引起的肾毒性和神经毒性的影响

本研究调查了山奈酚对以真空瓦斯油污染的嘎啦日粮喂养的 Wistar 大鼠组织的防御作用。将 30 只大鼠分为六组（n = 5）：组 1：对照组：油炸嘎啦正常饮食（FGND）。第 2 组和第 3 组：油炸嘎啦正常饮食（FGND），并分别添加 50 和 100 毫克/千克体重的山奈酚。第 4 组：仅添加真空气体油的油炸嘎啦饲料（FGD-VGO）。第 5 组和第 6 组给大鼠喂食 FGD-VGO，然后每公斤体重分别添加 50 和 100 毫克山奈酚。大鼠在 28 天的实验期结束后使用二氧化碳进行安乐死。切除组织（肾脏和大脑）进行生化检测。结果表明，与其他组相比，第 4 组大鼠组织中的抗氧化指标（超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽转移酶（GST））、Na+/K+-ATP 酶、脱氧核糖核酸（DNA）碎片百分比明显下降，丙二醛（MDA）增加。然而，使用山奈酚处理后，喂食脱硫剂-VGO 的大鼠组织中的 MDA 水平明显降低，抗氧化指标明显增加。总之，所获得的数据表明，山奈酚作为一种抗氧化剂，对 Wistar 大鼠食用掺有真空瓦斯油的嘎啦粉起到了至关重要的作用。

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