Role of long non-coding RNAs in depression: Mechanisms and potential therapeutic targets

IF 3.1 4区 医学 Q2 CLINICAL NEUROLOGY Journal of Neurorestoratology Pub Date : 2024-08-14 DOI:10.1016/j.jnrt.2024.100142
Zhanghua Ding , Juntian Shen , Chenlang Wei , Zhuocao Liu , Lina Huang , Shouhong Zhou
{"title":"Role of long non-coding RNAs in depression: Mechanisms and potential therapeutic targets","authors":"Zhanghua Ding ,&nbsp;Juntian Shen ,&nbsp;Chenlang Wei ,&nbsp;Zhuocao Liu ,&nbsp;Lina Huang ,&nbsp;Shouhong Zhou","doi":"10.1016/j.jnrt.2024.100142","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Depression, also known as major depressive disorder, is a mental disorder caused by multiple factors. The cause of depression remains unclear, but a growing number of studies have reported a link between depression and long non-coding RNAs (lncRNAs). In the present study, we reviewed the relationships between depression and four lncRNAs, focusing on the differential expression of these lncRNAs in patients with depression, how to regulate depression, and how to use lncRNAs for the diagnosis, prevention, and treatment of clinical depression.</p></div><div><h3>Methods</h3><p>A systematic review of 23 studies published between 2011 and 2021 was conducted using Pubmed. Selection criteria included publication date and relevance to topic: Only articles published after 2010 were included to ensure the review reflects the most recent research, and all articles are selected strictly on their research topic.</p></div><div><h3>Results</h3><p>The short communication has summarized the relationships between depression and four lncRNAs, especially antisense lncRNAs and lincRNAs, and their potential in the diagnosis of depression and its targeted therapy.</p></div><div><h3>Conclusions</h3><p>The study found that these four lncRNAs, particularly antisense lncRNAs and lincRNAs, are closely associated with various aspects of depression. These findings suggest new therapeutic targets and could contribute to improving the accuracy of depression diagnosis.</p></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"12 4","pages":"Article 100142"},"PeriodicalIF":3.1000,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2324242624000494/pdfft?md5=708764b86b1cf3042edff88a03ceae08&pid=1-s2.0-S2324242624000494-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurorestoratology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2324242624000494","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Depression, also known as major depressive disorder, is a mental disorder caused by multiple factors. The cause of depression remains unclear, but a growing number of studies have reported a link between depression and long non-coding RNAs (lncRNAs). In the present study, we reviewed the relationships between depression and four lncRNAs, focusing on the differential expression of these lncRNAs in patients with depression, how to regulate depression, and how to use lncRNAs for the diagnosis, prevention, and treatment of clinical depression.

Methods

A systematic review of 23 studies published between 2011 and 2021 was conducted using Pubmed. Selection criteria included publication date and relevance to topic: Only articles published after 2010 were included to ensure the review reflects the most recent research, and all articles are selected strictly on their research topic.

Results

The short communication has summarized the relationships between depression and four lncRNAs, especially antisense lncRNAs and lincRNAs, and their potential in the diagnosis of depression and its targeted therapy.

Conclusions

The study found that these four lncRNAs, particularly antisense lncRNAs and lincRNAs, are closely associated with various aspects of depression. These findings suggest new therapeutic targets and could contribute to improving the accuracy of depression diagnosis.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
长非编码 RNA 在抑郁症中的作用:机制和潜在治疗目标
背景抑郁症又称重度抑郁障碍,是一种由多种因素引起的精神障碍。抑郁症的病因尚不清楚,但越来越多的研究报告称抑郁症与长非编码 RNA(lncRNA)之间存在联系。在本研究中,我们回顾了抑郁症与四种lncRNAs之间的关系,重点探讨了这些lncRNAs在抑郁症患者中的差异表达、如何调节抑郁症以及如何利用lncRNAs诊断、预防和治疗临床抑郁症。选择标准包括发表日期和与主题的相关性:结果该短文总结了抑郁症与四种lncRNA(尤其是反义lncRNA和lincRNA)之间的关系,以及它们在抑郁症诊断和靶向治疗中的潜力。这些发现提示了新的治疗靶点,有助于提高抑郁症诊断的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Neurorestoratology
Journal of Neurorestoratology CLINICAL NEUROLOGY-
CiteScore
2.10
自引率
18.20%
发文量
22
审稿时长
12 weeks
期刊最新文献
Authors’ response to correspondence regarding “Application of deep brain stimulation and transcranial magnetic stimulation in stroke neurorestoration: A review” Response to the Letter from Dr. Li et al. for “Two Sides of One Coin: Neurorestoratology and Neurorehabilitation” Letter to Editor: Correspondence to "Two sides of one coin: Neurorestoratology and Neurorehabilitation" Corrigendum to “Comparison of chronic restraint stress-and lipopolysaccharide-induced mouse models of depression: Behavior, c-Fos expression, and microglial and astrocytic activation” [J Neurorestoratol 12 (2024) 100130] Editorial Board
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1