{"title":"Synthesis of water-soluble chlorambucil Janus dendrimers","authors":"","doi":"10.1016/j.tetlet.2024.155265","DOIUrl":null,"url":null,"abstract":"<div><p>In this paper we reported a new range of amphiphilic Janus dendrimers, which consist of sodium carboxylate and chlorambucil molecules as the peripheral groups, as novel potential anticancer dendritic drug delivery agents. The dendrons and structural features of the Janus dendrimers were analyzed by different techniques (<sup>1</sup>H, <sup>13</sup>C one- and two-dimension NMR spectroscopy, FTIR, UV–vis and mass spectrometry). The amphiphilic dendrimers were loaded with the water-insoluble anticancer drug, chlorambucil, by a covalent bond. The hydrophilic group, sodium carboxylate, was obtained from the Behera’s amine moieties. The Janus dendrimers take advantage of a dendritic display to carry different amounts of chlorambucil molecules. The Janus dendrimers chlorambucil-sodium-carboxylate as terminal groups were more active than its <em>tert</em>-butyl and OH substituted analogues against cancer cells. These results provide an effective entry to the development of new drug nanocarriers.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003605","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
In this paper we reported a new range of amphiphilic Janus dendrimers, which consist of sodium carboxylate and chlorambucil molecules as the peripheral groups, as novel potential anticancer dendritic drug delivery agents. The dendrons and structural features of the Janus dendrimers were analyzed by different techniques (1H, 13C one- and two-dimension NMR spectroscopy, FTIR, UV–vis and mass spectrometry). The amphiphilic dendrimers were loaded with the water-insoluble anticancer drug, chlorambucil, by a covalent bond. The hydrophilic group, sodium carboxylate, was obtained from the Behera’s amine moieties. The Janus dendrimers take advantage of a dendritic display to carry different amounts of chlorambucil molecules. The Janus dendrimers chlorambucil-sodium-carboxylate as terminal groups were more active than its tert-butyl and OH substituted analogues against cancer cells. These results provide an effective entry to the development of new drug nanocarriers.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.