Clinical Significance of Body Weight Loss During Chemotherapy for Advanced Gastric Cancer Undergoing Conversion Surgery.

IF 1.6 4区医学 Q4 ONCOLOGY Anticancer research Pub Date : 2024-09-01 DOI:10.21873/anticanres.17232

Takaaki Arigami, Daisuke Matsushita, Masataka Shimonosono, Yuki Hirase, Yusuke Tsuruda, Ken Sasaki, Kenji Baba, Takao Ohtsuka

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Abstract

Background/aim: The purpose of the present study was to assess the clinical impact of body weight loss (BWL) during chemotherapy in patients with initially unresectable advanced gastric cancer who underwent conversion surgery.

Patients and methods: This retrospective study included 61 patients with stage IV gastric cancer who underwent conversion surgery after chemotherapy, and body weight changes during chemotherapy were examined. Based on receiver operating characteristic (ROC) curve analysis of body weight change for disease recurrence, the cutoff value of BWL was determined. Based on the BWL cutoff value, patients were classified into two groups.

Results: Body weight change ranged from 28.2% to -21.8%. The cut-off value of BWL was set at 6% based on the ROC analysis. Of the 61 patients, 45 (74%) and 16 (26%) had <6% and ≥6% BWL, respectively. Patients with ≥6% BWL had peritoneal dissemination, pathological lymph node metastasis, residual tumor status of R1-2, and disease recurrence compared with those with <6% BWL (all p<0.05). The median survival times after conversion surgery were 21 and 63 months in the ≥6% and <6% BWL groups, respectively (p<0.01). Univariate analysis identified BWL as an independent prognostic factor (p=0.01), although histological response alone was significantly associated with survival in the multivariate analysis (p=0.02).

Conclusion: Patients with severe BWL during chemotherapy may be excluded from the indication of conversion surgery.

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接受转化手术的晚期胃癌患者化疗期间体重下降的临床意义

背景/目的：本研究的目的是评估化疗期间体重减轻（BWL）对接受转化手术的最初无法切除的晚期胃癌患者的临床影响：这项回顾性研究纳入了61例化疗后接受转化手术的IV期胃癌患者，并对化疗期间的体重变化进行了研究。根据体重变化对疾病复发的影响的接收者操作特征曲线（ROC）分析，确定了BWL的临界值。根据 BWL 临界值将患者分为两组：体重变化范围为 28.2% 至 -21.8%。根据 ROC 分析，BWL 临界值定为 6%。在 61 例患者中，45 例（74%）和 16 例（26%）有结论：化疗期间出现严重BWL的患者可排除在转换手术指征之外。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.