Neurodevelopmental Outcomes of Pediatric Cardiac Extracorporeal Membrane Oxygenation Survivors With Central Cannulation.

IF 1.9 4区医学 Q1 EDUCATION, SPECIAL Ajidd-American Journal on Intellectual and Developmental Disabilities Pub Date : 2024-09-01 DOI:10.1352/1944-7558-129.5.377

Ozlem Saritas Nakip, Selman Kesici, Gokcen Duzgun Konuskan, Mutlu Uysal Yazici, Bahadır Konuskan, Benan Bayrakci

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Abstract

Extracorporeal life support, such as pediatric cardiac extracorporeal membrane oxygenation (ECMO), is associated with significant mortality and morbidity risk. This study evaluated cardiac ECMO survivors with central cannulation and found that 51.1% were discharged from the hospital. The study also revealed high rates of developmental delay (82.7%), motor dysfunction (58.8%), and cognitive dysfunction (70.6%) among survivors. No significant correlation was found between the duration of ECMO, age at ECMO, pre-ECMO maximum lactate levels, and cognitive scores. Participants with motor dysfunction were significantly younger (p = 0.04). PRISM scores of those with an abnormal developmental status were significantly higher (p = 0.03). Logistic regression analysis did not show a significantly increased risk. Factors such as age, disease severity, and ECMO itself were identified as potential contributors to neurodevelopmental delay.

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使用中心插管的小儿体外膜肺氧合存活者的神经发育结果

体外生命支持，如小儿心脏体外膜肺氧合（ECMO），与显著的死亡率和发病率风险相关。这项研究对使用中心插管的心脏体外膜肺氧合存活者进行了评估，发现 51.1% 的存活者已出院。研究还发现，幸存者中发育迟缓（82.7%）、运动功能障碍（58.8%）和认知功能障碍（70.6%）的比例较高。ECMO 的持续时间、ECMO 时的年龄、ECMO 前的最大乳酸水平和认知评分之间没有发现明显的相关性。出现运动功能障碍的参与者明显更年轻（p = 0.04）。发育异常者的 PRISM 评分明显更高（p = 0.03）。逻辑回归分析并未显示风险明显增加。年龄、疾病严重程度和 ECMO 本身等因素被认为是导致神经发育迟缓的潜在因素。

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来源期刊

Ajidd-American Journal on Intellectual and Developmental Disabilities Multiple-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The American Journal on Intellectual and Developmental Disabilities (Print ISSN: 1944–7515; Online ISSN: 1944–7558) is published by the American Association on Intellectual and Developmental Disabilities. It is a scientifi c, scholarly, and archival multidisciplinary journal for reporting original contributions of the highest quality to knowledge of intellectual disabilities, its causes, treatment, and prevention.