{"title":"Primary thyroid lymphoma: A multi-center retrospective review","authors":"","doi":"10.1016/j.amjsurg.2024.115927","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Primary thyroid lymphoma (PTL) is rare and diagnosis is challenging.</p></div><div><h3>Methods</h3><p>We conducted a multicenter retrospective study of patients with PTL from 1990 to 2023 to determine method of diagnosis, treatment, and outcomes.</p></div><div><h3>Results</h3><p>The study cohort included 31 patients with PTL; all had thyroid enlargement; 21 (68 %) had compressive symptoms, 11 (35 %) had hypothyroidism and 3 had (10 %) B symptoms. Diagnosis was established from incisional biopsy in 8 (26 %), needle biopsy in 4 (13 %), excisional lymph node biopsy in 1 (3 %), and thyroidectomy specimens in 18 (58 %). 15 (48 %) patients had Hashimoto thyroiditis. Treatment included chemotherapy in 19 (61 %); surgery alone in 7 (23 %); and radiation alone or with surgery in 5 (16 %) patients. One (3 %) patient recurred, and 4 (13 %) patients died after a median 4.2 years.</p></div><div><h3>Conclusion</h3><p>Diagnosis of PTL was made in only 13 % of patients preoperatively. There may be opportunity for needle biopsy to facilitate earlier diagnosis and treatment.</p></div>","PeriodicalId":7771,"journal":{"name":"American journal of surgery","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002961024004793","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Primary thyroid lymphoma (PTL) is rare and diagnosis is challenging.
Methods
We conducted a multicenter retrospective study of patients with PTL from 1990 to 2023 to determine method of diagnosis, treatment, and outcomes.
Results
The study cohort included 31 patients with PTL; all had thyroid enlargement; 21 (68 %) had compressive symptoms, 11 (35 %) had hypothyroidism and 3 had (10 %) B symptoms. Diagnosis was established from incisional biopsy in 8 (26 %), needle biopsy in 4 (13 %), excisional lymph node biopsy in 1 (3 %), and thyroidectomy specimens in 18 (58 %). 15 (48 %) patients had Hashimoto thyroiditis. Treatment included chemotherapy in 19 (61 %); surgery alone in 7 (23 %); and radiation alone or with surgery in 5 (16 %) patients. One (3 %) patient recurred, and 4 (13 %) patients died after a median 4.2 years.
Conclusion
Diagnosis of PTL was made in only 13 % of patients preoperatively. There may be opportunity for needle biopsy to facilitate earlier diagnosis and treatment.
期刊介绍:
The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.