{"title":"Light-promoted AIBN-catalyzed oxidative cleavage of aryl olefins to aryl ketones","authors":"","doi":"10.1016/j.tet.2024.134211","DOIUrl":null,"url":null,"abstract":"<div><p>A convenient light-promoted 2,2-azobis(isobutyronitrile) (AIBN)-catalyzed synthesis of aryl ketone from aryl alkenes with molecular oxygen as the oxidant was developed. A series of aryl ketone were obtained in moderate to good yields. The new protocol features mild conditions and relatively broad substrate scope. The reaction was successfully applied for the synthesis of Fenofibrate in good yield. Based on previous documents and current experimental results, a plausible mechanism is proposed.</p></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402024003910","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A convenient light-promoted 2,2-azobis(isobutyronitrile) (AIBN)-catalyzed synthesis of aryl ketone from aryl alkenes with molecular oxygen as the oxidant was developed. A series of aryl ketone were obtained in moderate to good yields. The new protocol features mild conditions and relatively broad substrate scope. The reaction was successfully applied for the synthesis of Fenofibrate in good yield. Based on previous documents and current experimental results, a plausible mechanism is proposed.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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