Endoplasmic reticulum stress in abdominal aortic aneurysm

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS IJC Heart and Vasculature Pub Date : 2024-08-29 DOI:10.1016/j.ijcha.2024.101500
Zhaohai Su , Weiling Lu , Jun Cao , Zheng Xie , Pei Zhao
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Abstract

Abdominal aortic aneurysms (AAAs) are characterized by permanent dilatation of the abdominal aorta, which is accompanied by inflammation, degradation of the extracellular matrix (ECM) and disruption of vascular smooth muscle cell (VSMC) homeostasis. Endoplasmic reticulum (ER) stress is involved in the regulation of inflammation, oxidative stress and VSMC apoptosis, all of which are critical factors in AAA development. Although several studies have revealed the occurrence of ER stress in AAA development, the specific biological functions of ER stress in AAA development remain largely unknown. Given that targeting ER stress is a promising strategy for treating AAAs, further investigation of the physiological and pathological roles of ER stress in AAA development is warranted.

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腹主动脉瘤中的内质网应力
腹主动脉瘤(AAA)的特征是腹主动脉永久性扩张,同时伴有炎症、细胞外基质(ECM)降解和血管平滑肌细胞(VSMC)平衡的破坏。内质网(ER)应激参与了炎症、氧化应激和血管平滑肌细胞凋亡的调控,所有这些都是 AAA 发生的关键因素。尽管多项研究揭示了ER应激在AAA发生发展过程中的存在,但ER应激在AAA发生发展过程中的具体生物学功能在很大程度上仍然未知。鉴于靶向 ER 应激是治疗 AAA 的一种有前景的策略,有必要进一步研究 ER 应激在 AAA 发生过程中的生理和病理作用。
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来源期刊
IJC Heart and Vasculature
IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine
CiteScore
4.90
自引率
10.30%
发文量
216
审稿时长
56 days
期刊介绍: IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.
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