Prognostic roles of neutrophil–lymphocyte, monocyte-lymphocyte and platelet-lymphocyte ratios for long-term all-cause mortality in heart failure

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS IJC Heart and Vasculature Pub Date : 2024-08-31 DOI:10.1016/j.ijcha.2024.101502
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Abstract

Background

Heart failure (HF) and inflammation have a bidirectional relation leading to activation and adaptation of multiple cellular lines, including leucocyte subtypes and platelets. We aimed to assess and compare the predictive value of the neutrophil–lymphocyte (NLR), monocyte-lymphocyte (MLR) and platelet-lymphocyte (PLR) ratios for all-cause long-term mortality in HF.

Methods

This is an observational retrospective cohort study that included patients from the HI-HF cohort that survived the initial hospitalization. Vital status and survival time were assessed in June 2020.

Results

We analyzed 1018 HF patients with a mean age of 72.32 ± 10.29 years and 53.54 % women. All-cause long-term mortality was 38.21 % after a median follow-up time of 68 [38 – 82] months. NLR (AUC 0.667, 95 %CI 0.637 – 0.697), MLR (AUC 0.670, 95 %CI 0.640 – 0.700) and PLR (AUC 0.606, 95 %CI 0.574 – 0.636) were predictors of all-cause mortality. In multivariable Cox proportional hazards analysis, NLR≥3.56 was the only hematological index independent predictor of fatality (HR 1.36, 95 %CI 1.05 – 1.76).

Conclusions

Of the three hematological indices, NLR was the only independent predictor of all-cause long-term mortality of HF patients. We suggest NLR≥3.56 as an auxiliary prognostic biomarker for the evaluation of HF patients.

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中性粒细胞-淋巴细胞、单核细胞-淋巴细胞和血小板-淋巴细胞比率对心力衰竭长期全因死亡率的预后作用
背景心力衰竭(HF)和炎症有双向关系,导致多种细胞系(包括白细胞亚型和血小板)的活化和适应。我们的目的是评估和比较中性粒细胞-淋巴细胞(NLR)、单核细胞-淋巴细胞(MLR)和血小板-淋巴细胞(PLR)比率对心力衰竭患者全因长期死亡率的预测价值。结果我们分析了 1018 名高血压患者,平均年龄(72.32 ± 10.29)岁,女性占 53.54%。中位随访时间为 68 [38 - 82] 个月,全因长期死亡率为 38.21%。NLR(AUC 0.667,95 %CI 0.637 - 0.697)、MLR(AUC 0.670,95 %CI 0.640 - 0.700)和PLR(AUC 0.606,95 %CI 0.574 - 0.636)是预测全因死亡率的指标。在多变量 Cox 比例危险分析中,NLR≥3.56 是唯一独立预测死亡的血液指标(HR 1.36,95 %CI 1.05 - 1.76)。我们建议将 NLR≥3.56 作为评估心房颤动患者预后的辅助生物标志物。
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来源期刊
IJC Heart and Vasculature
IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine
CiteScore
4.90
自引率
10.30%
发文量
216
审稿时长
56 days
期刊介绍: IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.
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