{"title":"Benzothieno[c]quinoline based a novel fluorescent “turn-on” chemosensor for the detection of Fe (III) from aqueous solution","authors":"","doi":"10.1016/j.ica.2024.122342","DOIUrl":null,"url":null,"abstract":"<div><p>A 6-(thiophen-2-yl)benzo[4,5]thieno[3,2-<em>c</em>]quinoline (QTP), with thiophene and quinoline based moieties as binding sites, has been synthesized and characterized with spectroscopic methods, and DFT. The synthesized probe QTP showed highly sensitive and highly specific fluorescent ‘turn-on’ effect (λem = 280 nm) for the 1:1 binding with Fe<sup>3+</sup> ions to form probe QTP.Fe<sup>3+</sup> complex in semi-aqueous medium (acetonitrile:water (50:50; v/v)) and live cells. The 1:1 binding stoichiometry of probe QTP and Fe<sup>3+</sup> ions were proposed by DFT calculations and confirmed by the NMR spectroscopy, and mass spectrum of probe QTP.Fe<sup>3+</sup> complex. Importantly, with the LOD 6.37 µM for the detection of Fe<sup>3+</sup> ions, receptor QTP did not show any interference from potentially competing ions, indicates its biocompatibility. The micromolar limit of detection (6.37 µM), cell permeability, and low cytotoxicity allows the probe QTP to be an outstanding tool for the live-cell imaging and detection of ferric ions in live cells.</p></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002016932400433X","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
A 6-(thiophen-2-yl)benzo[4,5]thieno[3,2-c]quinoline (QTP), with thiophene and quinoline based moieties as binding sites, has been synthesized and characterized with spectroscopic methods, and DFT. The synthesized probe QTP showed highly sensitive and highly specific fluorescent ‘turn-on’ effect (λem = 280 nm) for the 1:1 binding with Fe3+ ions to form probe QTP.Fe3+ complex in semi-aqueous medium (acetonitrile:water (50:50; v/v)) and live cells. The 1:1 binding stoichiometry of probe QTP and Fe3+ ions were proposed by DFT calculations and confirmed by the NMR spectroscopy, and mass spectrum of probe QTP.Fe3+ complex. Importantly, with the LOD 6.37 µM for the detection of Fe3+ ions, receptor QTP did not show any interference from potentially competing ions, indicates its biocompatibility. The micromolar limit of detection (6.37 µM), cell permeability, and low cytotoxicity allows the probe QTP to be an outstanding tool for the live-cell imaging and detection of ferric ions in live cells.
期刊介绍:
Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews.
Topics covered include:
• chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies;
• synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs);
• reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models;
• applications of inorganic compounds, metallodrugs and molecule-based materials.
Papers composed primarily of structural reports will typically not be considered for publication.