Carmen Serrano-Rísquez, Mohamed Omar, Norma Rallón, José Miguel Benito, Amparo Gómez-Vidal, Francisco José Márquez, Martina Alján, Antonio Rivero-Juárez, Ignacio Pérez-Valero, Antonio Rivero, Faruk Sinangil, Irma Saulle, Mara Biasin, Mario Clerici, Donald Forthal, Maria Eugenia Saéz, Antonio Caruz
{"title":"Impact of HLA allele-KIR partners on sexually transmitted HIV-1 infection","authors":"Carmen Serrano-Rísquez, Mohamed Omar, Norma Rallón, José Miguel Benito, Amparo Gómez-Vidal, Francisco José Márquez, Martina Alján, Antonio Rivero-Juárez, Ignacio Pérez-Valero, Antonio Rivero, Faruk Sinangil, Irma Saulle, Mara Biasin, Mario Clerici, Donald Forthal, Maria Eugenia Saéz, Antonio Caruz","doi":"10.1093/infdis/jiae436","DOIUrl":null,"url":null,"abstract":"HLA-I/KIR genotypes influence HIV-1 disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route—parenteral vs. sexual—may influence this association. We conducted a GWAS in a population of people living with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/infdis/jiae436","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
HLA-I/KIR genotypes influence HIV-1 disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route—parenteral vs. sexual—may influence this association. We conducted a GWAS in a population of people living with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.
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