Acetonitrile Regeneration from Oligonucleotide Production Waste Streams

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED Organic Process Research & Development Pub Date : 2024-08-30 DOI:10.1021/acs.oprd.4c00188

Ruairí Ó Meadhra, Christian Fleury, Bertrand Guelat, Francesco Venturoni

引用次数: 0

Abstract

A distillation concept is described to process organic and aqueous waste streams from an oligonucleotide process to regenerate 85% of acetonitrile contained in the wastes, for reintroduction back into the oligonucleotide process. Careful selection of the streams to send to regeneration based on their acetonitrile content was shown to simplify the number of processing steps and minimize the size of the equipment required for regeneration. Availability of accurate vapor–liquid equilibrium data was shown to be key to designing the number of processing steps, the operating conditions, and calculating purification performance. A modified classical two-column distillation pressure swing dewatering system with an intermediate-pressure column for the separation of light boilers, was shown to effectively purify and dewater acetonitrile to the required specifications. Aspen Plus software was used to generate vapor–liquid equilibrium (VLE) data and simulate process alternatives.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

从寡核苷酸生产废水中再生乙腈

描述了一种蒸馏概念，用于处理来自寡核苷酸工艺的有机废液和水废液，以再生废液中所含的 85% 乙腈，并将其重新引入寡核苷酸工艺。事实证明，根据乙腈含量仔细选择要送去再生的废液流，可以简化处理步骤的数量，并最大限度地减少再生所需的设备体积。准确的汽液平衡数据是设计处理步骤数量、操作条件和计算纯化性能的关键。研究表明，改进后的经典双塔蒸馏变压脱水系统带有一个用于分离轻质锅炉的中间压力塔，可以有效地净化和脱水乙腈，使其达到所需的规格。Aspen Plus 软件用于生成汽液平衡 (VLE) 数据和模拟替代工艺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.

期刊最新文献

Issue Publication Information Issue Editorial Masthead Practical, Large-Scale Preparation of Ni(tmeda)(o-tol)Cl Practical and Efficient Approach to Scalable Synthesis of Rucaparib Chemical and Biochemical Approaches to an Enantiomerically Pure 3,4-Disubstituted Tetrahydrofuran Derivative at a Multikilogram Scale: The Power of KRED