Rh(III)-Catalyzed Sequential ortho-C-H Bond Annulation and Desulfonylation of 3-Aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides: Access to 1-Aminoisoquinolines.
B V Subba Reddy, Chidrawar Ajay, Sridhar Balasubramanian
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Abstract
An efficient Rh(III)-catalyzed C-H functionalization of 3-aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides with diaryl and dialkyl alkynes has been developed for the first time to the synthesis of 1-aminoisoquinoline derivatives in a single step. This method involves through the formation of two C-C bonds and one C-N bond followed by desulfonylation to generate a novel series of isoquinolines in good to excellent yields. This is a direct method to produce pharmaceutically more relevant scaffolds with a high functional diversity.
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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