Occupational exposure to benzene and risk of non-Hodgkin lymphoma in an extended follow-up of two population-based prospective cohorts of Chinese men and women.
Bryan A Bassig, Xiao-Ou Shu, Melissa C Friesen, Roel Vermeulen, Mark P Purdue, Bu-Tian Ji, Gong Yang, Jason Y Y Wong, Nathan Appel, Wei Hu, Yu-Tang Gao, Wei Zheng, Nathaniel Rothman, Qing Lan
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引用次数: 0
Abstract
The carcinogenicity of benzene was reevaluated by the International Agency for Research on Cancer in 2017, with the Working Group reaffirming positive yet inconclusive associations with non-Hodgkin lymphoma (NHL). To extend our previous observation of a significant exposure-response for cumulative occupational benzene exposure and NHL risk among Chinese women in a population-based cohort in Shanghai, we extended follow-up of this cohort and pooled the data with a similarly designed population-based cohort of men in Shanghai. Cumulative exposure estimates were derived for 134,449 participants in the pooled analysis by combining ordinal job-exposure matrix intensity ratings with quantitative benzene measurements from an inspection database of Shanghai factories. Associations between benzene exposure metrics and NHL (n = 363 cases including multiple myeloma [MM]) were assessed using Cox proportional hazard models. Ever occupational exposure to benzene in the pooled population was associated with NHL risk (HR = 1.5, 95% CI = 1.2-2.0), and exposure-response relationships were observed for increasing duration (ptrend = .003) and cumulative exposure (ptrend = .003). Associations with ever exposure, duration, and cumulative exposure were similar for NHL with and without MM in the case definition, including lifetime cumulative exposures in the highest quartile (HR = 1.6, 95% CI = 1.1-2.4 with MM included; HR = 1.7, 95% CI = 1.1-2.7 with MM excluded). An elevated risk of the chronic lymphocytic leukemia subtype was suggested in the pooled analyses (HR for ever vs. never exposure = 2.3, 95% CI = 0.9-5.6). These observations provide additional support for a plausible association between occupational benzene exposure and risk of NHL.
国际癌症研究机构于 2017 年对苯的致癌性进行了重新评估,工作组重申苯与非霍奇金淋巴瘤(NHL)之间存在积极但尚无定论的关联。为了扩展我们之前在上海一个基于人群的队列中观察到的中国女性累积职业苯暴露与 NHL 风险之间存在显著的暴露反应,我们延长了对该队列的随访,并将数据与设计类似的上海男性人群队列进行了汇总。通过将工作暴露矩阵强度等级序数与上海工厂检测数据库中的苯定量测量值相结合,得出了汇总分析中 134,449 名参与者的累积暴露估计值。采用 Cox 比例危险模型评估了苯暴露指标与 NHL(n = 363 例,包括多发性骨髓瘤 [MM])之间的关系。汇总人群中的苯职业暴露与 NHL 风险相关(HR = 1.5,95% CI = 1.2-2.0),暴露-反应关系随着持续时间(ptrend = .003)和累积暴露(ptrend = .003)的增加而增加。在病例定义中,有 MM 和没有 MM 的 NHL 与曾经暴露、持续时间和累积暴露的关系相似,包括最高四分位数的终生累积暴露(包括 MM 时,HR = 1.6,95% CI = 1.1-2.4;不包括 MM 时,HR = 1.7,95% CI = 1.1-2.7)。汇总分析表明,慢性淋巴细胞白血病亚型的风险升高(曾经接触与从未接触的 HR = 2.3,95% CI = 0.9-5.6)。这些观察结果进一步证实了职业苯暴露与 NHL 风险之间存在合理的联系。
期刊介绍:
The International Journal of Cancer (IJC) is the official journal of the Union for International Cancer Control—UICC; it appears twice a month. IJC invites submission of manuscripts under a broad scope of topics relevant to experimental and clinical cancer research and publishes original Research Articles and Short Reports under the following categories:
-Cancer Epidemiology-
Cancer Genetics and Epigenetics-
Infectious Causes of Cancer-
Innovative Tools and Methods-
Molecular Cancer Biology-
Tumor Immunology and Microenvironment-
Tumor Markers and Signatures-
Cancer Therapy and Prevention