Impact of systemic hypertension on inner retinal layer thickness and macular microvasculature in patients with diabetic retinopathy.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Acta Diabetologica Pub Date : 2024-08-27 DOI:10.1007/s00592-024-02355-5

Hwa-Young Yu, Jae-Jun Kim, Jung-Tae Kim, Min-Woo Lee

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Abstract

Aim: To investigate the effects of hypertension (HTN) on inner retinal thickness and macular microvasculature in patients with diabetic retinopathy (DR).

Methods: Subjects were classified into three groups: patients with type 2 diabetes mellitus (T2DM) (T2DM group), patients with DR (DR-HTN group), and patients with DR and HTN (DR + HTN group). The ganglion cell complex (GCC) thicknesses and the macular vessel density (VD) were compared. Linear regression analyses were performed to identify factors associated with the VD in the DR + HTN group.

Results: The mean GCC thicknesses were 112.2 ± 12.3, 109.2 ± 13.7, and 106.2 ± 11.2 μm in the T2DM, DR-HTN, and DR + HTN groups, respectively (P = 0.045). The mean VDs were 25.4 ± 5.0, 24.3 ± 8.9, and 21.2 ± 7.1% (P = 0.014) for the superficial capillary plexus (SCP) and 25.9 ± 4.3, 22.9 ± 8.5, and 20.2 ± 6.6% (P < 0.001) for the deep capillary plexus (DCP) in the T2DM, DR-HTN, and DR + HTN groups, respectively. In multivariate analyses, the duration of HTN was a significant factor associated with the VD of both SCP (B = -0.24, P = 0.010) and DCP (B = -0.21, P = 0.016).

Conclusions: Patients with both DR and HTN had a thinner GCC and lower VDs of SCP and DCP than those with DR alone. These outcomes could be associated with the synergistic ischemic effects in DR patients with HTN. Moreover, the duration of HTN in DR patients was significantly associated with macular VD in both SCP and DCP.

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全身性高血压对糖尿病视网膜病变患者视网膜内层厚度和黄斑微血管的影响。

目的：研究高血压（HTN）对糖尿病视网膜病变（DR）患者视网膜内层厚度和黄斑微血管的影响：将受试者分为三组：2 型糖尿病（T2DM）患者（T2DM 组）、DR 患者（DR-HTN 组）以及 DR 和 HTN 患者（DR + HTN 组）。比较了神经节细胞复合体（GCC）厚度和黄斑血管密度（VD）。对 DR + HTN 组进行线性回归分析，以确定与 VD 相关的因素：结果：T2DM 组、DR-HTN 组和 DR + HTN 组的平均 GCC 厚度分别为 112.2 ± 12.3、109.2 ± 13.7 和 106.2 ± 11.2 μm（P = 0.045）。表层毛细血管丛（SCP）的平均 VD 分别为 25.4 ± 5.0、24.3 ± 8.9 和 21.2 ± 7.1%（P = 0.014），浅层毛细血管丛（SCP）的平均 VD 分别为 25.9 ± 4.3、22.9 ± 8.5 和 20.2 ± 6.6%（P 结论：表层毛细血管丛（SCP）和浅层毛细血管丛（SCP）的平均 VD 分别为 25.4 ± 5.0、24.3 ± 8.9 和 21.2 ± 7.1%（P = 0.014）：与单独患有 DR 的患者相比，同时患有 DR 和高血压的患者的 GCC 较薄，SCP 和 DCP 的 VD 较低。这些结果可能与 DR 患者合并高血压的协同缺血效应有关。此外，DR 患者的高血压持续时间与 SCP 和 DCP 的黄斑 VD 显著相关。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.